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74936-93-9

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74936-93-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 74936-93-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,9,3 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 74936-93:
(7*7)+(6*4)+(5*9)+(4*3)+(3*6)+(2*9)+(1*3)=169
169 % 10 = 9
So 74936-93-9 is a valid CAS Registry Number.

74936-93-9Downstream Products

74936-93-9Relevant articles and documents

SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF

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Page/Page column 82, (2019/06/05)

The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS)

Edfeldt, Fredrik,Even?s, Johan,Lepist?, Matti,Ward, Alison,Petersen, Jens,Wissler, Lisa,Rohman, Mattias,Sivars, Ulf,Svensson, Karin,Perry, Matthew,Feierberg, Isabella,Zhou, Xiao-Hong,Hansson, Thomas,Narjes, Frank

, p. 2496 - 2500 (2015/06/02)

Abstract Human H-PGDS has shown promise as a potential target for anti-allergic and anti-inflammatory drugs. Here we describe the discovery of a novel class of indole inhibitors, identified through focused screening of 42,000 compounds and evaluated using a series of hit validation assays that included fluorescence polarization binding, 1D NMR, ITC and chromogenic enzymatic assays. Compounds with low nanomolar potency, favorable physico-chemical properties and inhibitory activity in human mast cells have been identified. In addition, our studies suggest that the active site of hH-PGDS can accommodate larger structural diversity than previously thought, such as the introduction of polar groups in the inner part of the binding pocket.

Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino) isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor

Rode, Haridas B.,Sos, Martin L.,Grütter, Christian,Heynck, Stefanie,Simard, Jeffrey R.,Rauh, Daniel

experimental part, p. 429 - 439 (2011/02/27)

Here we present the synthesis and biological activity of a series of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase (MLCK) and the epidermal growth factor receptor kinase (EGFR). The inhibitory

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