10077-32-4

Upstream product

• 140-29-4 phenylacetonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 5432-07-5 (Z)-3-(4-methoxyphenyl)-2-phenylacrylonitrile 
• 104-47-2 p-methoxybenzylnitrile 
• 34906-70-2 (4-dimethylamino-phenyl)-acetonitrile 

Downstream Products

• 32970-78-8 2-phenyl-3-(4-methoxyphenyl)-propylnitrile 
• 52921-24-1 dimethyl 3-(4-methoxyphenyl)-1H-pyrrole-2,4-dicarboxylate 
• 80654-51-9 2-[3-(4-Methoxy-phenyl)-2-phenyl-propylamino]-1-phenyl-ethanol 
• 5636-50-0 3-(4-methoxy-phenyl)-2-phenyl-propylamine 

Relevant academic research and scientific papers

Accelerated Discovery of α-Cyanodiarylethene Photoswitches

Cyanodiarylethene chromophores are able to undergo constitutional exchange via dynamic covalent chemistry (DCC). During this process, the central ethylene bridge of the molecular scaffold can be broken and thereby enables the assembly of a new combination of aryl moieties around the reformed ethylene bridge. The reversible CC double bond exchange has exemplarily been investigated using α-cyanostilbenes. Establishing a dynamic equilibrium reaction from α-cyanodiarylethene with arylacetonitriles under mild conditions has been the basis to access constitutional libraries of new photoswitches with potentially improved properties. When subject to irradiation with light of adequate wavelength, α-cyanodiarylethenes undergo Z/E isomerization followed by ring-closure. By screening the thus accessible dynamic chromophore libraries using a desired detection wavelength, we could identify specific dithienyl analogues that exhibit three-state photochromism. The combination of dynamic constitutional libraries of functional chromophores in combination with the light-guided screening and selection should lead to more rapid exploration of structural diversity dye chemistry.

Facile synthesis of new functionalized 3,4-dihydro-2H-pyrroles using 2-isocyanoacetates

A one-step synthesis of novel functionalized 3,4-dihydro-2H-pyrroles from 2-isocyanoacetates and readily synthesized acrylonitriles is reported. The reaction proceeds smoothly under mild conditions with high efficiency. The structures of two representativ

Magnetic nanoparticle supported amine: An efficient and environmental benign catalyst for versatile Knoevenagel condensation under ultrasound irradiation

Amine functionalized silica coated Fe3O4 nanoparticles (SiO2@MNP-A) were successfully prepared as a novel heterogeneous amine. The catalyst was characterized by XRD, FT-IR, TEM, magnetic measurement, elemental analysis and was found to be a magnetically separable and highly active catalyst for ambient Knoevenagel condensation of aromatic aldehydes and a-aromatic (heteroaromatic or polyaromatic)-substituted methylene compounds in water under ultrasonic irradiation to afford the corresponding products in good to excellent yields. Very interestingly, SiO2@MNP-A successfully catalyze the reaction of the non-cyano substituted compound with benzaldehyde to achieve a key intermediate for the preparation of Atorvastatin calcium in green and atom-economic manner. In addition, the catalyst SiO2@MNP-A can be reused for 8 times without any obvious loss of its activity. The role of ultrasonication in the Knoevenagel condensation was also discussed with the assistance of UV-vis spectrometry.