100779-91-7

Usage

Uses

Used in Organic Synthesis:
1-(3-BROMOPROPYL)PYRROLE is used as a building block in organic synthesis for its ability to contribute to the formation of complex organic molecules. Its unique structure allows it to be a versatile component in the creation of various chemical compounds.
Used in Pharmaceutical Industry:
1-(3-BROMOPROPYL)PYRROLE is used as a constituent in the development of pharmaceuticals, potentially due to its reactivity and the possibility of it being incorporated into drug molecules to treat specific medical conditions.
Used in Chemical Research:
In the field of chemical research, 1-(3-BROMOPROPYL)PYRROLE serves as a subject of study to explore its properties, reactivity, and potential applications in advancing scientific knowledge and the discovery of new materials or compounds.

InChI:InChI=1/C7H10BrN/c8-4-3-7-9-5-1-2-6-9/h1-2,5-6H,3-4,7H2

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 5003-71-4 3-bromopropylamine hydrochloride 
• 109-97-7 pyrrole 
• 109-64-8 1,3-dibromo-propane 
• 50966-69-3 3-pyrrol-1-yl-propan-1-ol 

Downstream Products

• 197141-94-9 (R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid 
• 443305-67-7 (R)-methyl 1-(2-aminophenyl)-8-ethyl-8-vinyl-5,6,7,8-tetrahydroindolizine-3-carboxylate 
• 50966-69-3 3-pyrrol-1-yl-propan-1-ol 

Relevant academic research and scientific papers

Synthesis and spectroscopic characterization of a fluorescent pyrrole derivative containing electron acceptor and donor groups

The synthesis and fluorescence characterization of a new pyrrole derivative (PyPDG) containing the electron donor-acceptor dansyl substituent is reported. The effects of temperature and solvent polarity on the steady-state fluorescence of this compound are investigated. Our results show that PyPDG exhibits desirable fluorescent properties which makes it a promising candidate to be used as the photoactive material in optical thermometry and thermography applications. Further, the electrochemical and emission properties of polymeric films obtained from the oxidation polymerization of PyPDG are also analyzed.

Synthesis of (R)-(-) and (S)-(+)-3-(1-pyrrolyl)propyl- N-(3,5- dinitrobenzoyl)-α-phenylglycinate and derivatives. A suitable chiral polymeric phase precursor

A synthetic route to obtain (R)-(-) (1), (S)-(+)-3-(1-pyrrolyl)propyl-N- (3,5-dinitrobenzoyl)-α-phenylglycinate (2) and derivatives is described. In a first step, pyrrole derivatives were prepared using the Clauson-Kaas method. The esterification, second step, was performed using basic conditions due to sensitivity of the pyrrole group toward acidic conditions. A tautomeric equilibrium involving the stereogenic center induces the product epimerization. The substitution of DMAP and Et3N by a highly hindered base, proton-sponge, furnished the final products without racemization. The ee of 1, 2 and of the corresponding methyl esters (3 and 4) were determined by 1H NMR analysis in the presence of optically active Eu(tfc)3. Epimerization was not observed in the preparation of the carboxylate salts (5-8).

Viologen(2+/1+) and Viologen(1+/0) Electron-Self-Exchange Reactions in a Redox Polymer

A analysis is given of the electron-self-exchange reactions responsible for the steady-state redox conductivity of thin films of the electropolymerized monomer N,N'-bis(3-pyrrol-1-yl-propyl)-4,4'-bipyridinium tetrafluoroborate, sandwiched between two electrodes.Concentration-gradient-driven electron self-exchange in the liquid-acetonitrile-bathed viologen(2+/1+) mixed-valent state of this polymer, kex = 8 x 103 M-1 s-1, is much slower than that for the viologen (1+/0) mixed valent-state, kex = 1.6 x 105 M-1 s-1, which has a smaller activation barrier.Neither self-exchange reaction responds to use of alternative counterions except that both rates decrease in polymer containing tosylate counterions.The rate constant found for the electrical-gradient-driven viologen (1+/0) electron self-exchange, kex = 1.1 x 105 M-1 s-1, observed in dry, N2-bathed polymer where ClO4(1-) counterion mobility is quenched, is nearly the same as the acetonitrile-bathed value.The rate constants appear to be dominated by characteristics of the polymer phase rather than the bathing environment of the polymer.Estimates are made of the counteranion diffusivity in acetonitrile-bathed films and of how it affects transient electron transport measurements.

Electropolymerized biotinylated poly (pyrrole-viologen) film as platform for the development of reagentless impedimetric immunosensors

We describe herein the synthesis and electrochemical polymerization of a viologen monomer functionalized by a biotin group and the use of its redox properties for the impedimetric sensing of protein binding. The electrochemical oxidation of the pyrrole group at 0.85 V in CH3CN led to a biotinylated polypyrrole film allowing the successive anchoring of an avidin layer and a biotinylated cholera toxin layer. EIS performed at -0.45 V/SCE without redox probe in solution showed the specific immobilization of the anti-cholera toxin antibody.

Synthesis of Vitamin-B12 Derivatives with an Electropolymerizable Side Chain

Three new derivatives of vitamin B12 with a pyrrole head group attached to the corrin ring have been prepared. Ligand-exchange reactions and reduction provided reactive CoIII and CoII complexes. Their electrochemical properties and their potential for fixation at the surface of electrodes by electropolymerization were studied.

A nitrite biosensor based on a maltose binding protein nitrite reductase fusion immobilized on an electropolymerized film of a pyrrole-derived bipyridinium

The preparation and electrochemical characterization of glassy carbon electrodes (GCEs) modified with electropolymerized films of the cation N-(3-pyrrol-1-yl-propyl)-4,4′-bipyridine (PPB) are described. The behavior of a new biosensor, which exhibits a high catalytic activity for nitrite reduction and which consists of a maltose binding protein nitrite reductase fusion (MBP-Nir) immobilized on an electropolymerized film of PPB as an electrocatalyst, is also described. The insoluble perchlorate salt of the poly(benzjl viologen) dication was used to immobilize MBP-Nir onto an electrode previously modified with an electropolymerized film of PPB. The electropolymerized film of PPB on the GCE is redox active and exhibits special electron-transfer properties toward the MBP-Nir layer but not toward Nir (Nir without MBP fusion attached), suggesting an intimate interaction between the PPB film and the MBP-Nir layer. The kinetics of the catalytic reaction between the biosensor and nitrite anion were characterized using cyclic voltammetry and rotated disk electrode techniques, and a value of (4.6 ± 0.5) × 103 M-1 s-1 was obtained for the rate constant.

A stimulus-responsive poly-pyrrole nano tube targeted drug carrier and its preparation method

The invention provides a stimulus-response type polypyrrole nanotube targeting drug carrier and a preparation method. A titanium dioxide nanotube array or a porous anodic alumina array serves as a template, and a polypyrrole nanotube is prepared through chemical vapor deposition; beta-cyclodextrin and a tube opening of a polypyrrole nanotube are connected through stimulus response type sensitive bonds such as acyl hydrazone bonds and disulfide bonds, and medicine can be blocked in the nanotube and released out in the faintly acid and reducibility environments; one end of a polyethylene glycol chain is connected with a folic acid targeted molecule, the other end of the polyethylene glycol chain is connected with an adamantane head base, the adamantane head base is linked up to a beta-cyclodextrin hydrophobic cavity through host and guest envelope, and folic acid molecules recognize tumor cells through a receptor-ligand medium. The stimulus-response type polypyrrole nanotube targeting drug carrier prepared through the method is uniform in particle diameter size distribution, controllable in appearance, stable in product, simple in synthesis process, low in cost and suitable for mass production.

FLAVIN DERIVATIVES

The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.

FLAVIN DERIVATIVES

The present invention relates novel flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives.

Preparation of annulated nitrogen-containing heterocycles via a one-pot palladium-catalyzed alkylation/direct arylation sequence

A palladium-catalyzed/norbornene-mediated sequential coupling reaction involving an aromatic sp2 C-H functionalization as the key step is described, in which an alkyl-aryl bond and an aryl-heteroaryl bond are formed in one pot. A variety of hig