50966-69-3Relevant articles and documents
Organic synthesis via magnetic attraction: Benign and sustainable protocols using magnetic nanoferrites
Nasir Baig,Varma, Rajender S.
, p. 398 - 417 (2013/03/14)
Magnetic nano-catalysts have been prepared using simple modification of iron ferrites. The nm size range of these particles facilitates the catalysis process, as an increased surface area is available for the reaction; the easy separation of the catalysts by an external magnet and their recovery and reuse are additional beneficial attributes. Glutathione bearing nano-ferrites have been used as organocatalysts for the Paal-Knorr reaction and homocoupling of boronic acids. Nanoferrites, post-synthetically modified by ligands, were used to immobilize nanometals (Cu, Pd, Ru, etc.) which enabled the development of efficient, sustainable and green procedures for azide-alkynes-cycloaddition (AAC) reactions, C-S coupling, O-allylation of phenol, Heck-type reactions and hydration of nitriles.
Enantioselective Fujiwara-Moritani indole and pyrrole annulations catalyzed by chiral palladium(II)-NicOx complexes
Schiffner, Julia A.,Woeste, Thorsten H.,Oestreich, Martin
supporting information; experimental part, p. 174 - 182 (2010/04/02)
The catalytic asymmetric Fujiwara-Moritani ring closures of several indole-and pyrrole-based cyclization precursors are reported. These unprecedented oxidative palladium(II)-catalyzed annulations allow for the formation of a stereogenic quaternary carbon atom, and decent levels of enantiocontrol are seen in 5-exo-trig cyclizations (54% ee for an indole and 76% ee for a pyrrole) while 6-exo-trig ring closures afford essentially racemic material. Novel oxazoline ligands with a nicotine platform (NicOx) are pivotal for good catalytic turnover as conventional PyOx ligands failed to produce acceptable chemical yields. The preparation of these NicOx ligands as well as the syntheses of the cyclization precursors are described in detail.
Magnetic nanoparticle-supported glutathione: A conceptually sustainable organocatalyst
Polshettiwar, Vivek,Baruwati, Babita,Varma, Rajender S.
supporting information; experimental part, p. 1837 - 1839 (2009/10/23)
A conceptually novel nanoparticle-supported and magnetically recoverable organocatalyst has been developed, which is readily prepared from inexpensive starting materials in a truly sustainable manner; which catalyzes the Paal-Knorr reaction with high yield in pure aqueous medium that avoids the use of toxic organic solvents, even in the workup step.
