50966-69-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-Hydroxypropyl)pyrrole is used as a pharmaceutical compound for its potential biological activity. Its unique structure may contribute to the development of new drugs or therapeutic agents, particularly in the areas of medicinal chemistry and drug discovery.
Used in Chemical Industry:
In the chemical industry, 1-(3-Hydroxypropyl)pyrrole serves as a building block for the synthesis of other complex organic compounds. Its versatile structure allows for further functionalization and incorporation into a wide range of chemical products, including specialty chemicals, materials, and intermediates for various applications.
Used in Research and Development:
1-(3-Hydroxypropyl)pyrrole is utilized as a research compound in the fields of chemistry and biotechnology. Its unique properties and structure make it an interesting target for exploring new reactions, mechanisms, and potential applications, contributing to the advancement of scientific knowledge and innovation in these disciplines.

Upstream product

• 89059-06-3 N-(2-carboxyethyl)pyrrole 
• 109-97-7 pyrrole 
• 627-30-5 1-chloro-3-hydroxypropane 
• 100779-91-7 1-(3-bromopropyl)-1H-pyrrole 
• 16199-06-7 potassium pyrrolide 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 156-87-6 propan-1-ol-3-amine 
• 627-18-9 1-bromo-3-propanol 

Downstream Products

• 100890-92-4 toluene-4-sulfonic acid-3-pyrrol-1-yl-propyl ester 
• 440370-07-0 4-(3-pyrrol-1-ylpropoxy)phthalonitrile 
• 599199-21-0 3-benzoyl-benzoic acid 3-pyrrol-1-yl-propyl ester 
• 100779-91-7 1-(3-bromopropyl)-1H-pyrrole 
• 176172-86-4 Ni(C₂₀H₈N₄(C₆F₄O(CH₂)3NC₄H₄)(C₆F₅)3) 
• 176172-87-5 Ni(C₂₀H₈N₄(C₆F₄O(CH₂)3NC₄H₄)2(C₆F₅)2) 
• 176172-88-6 Ni(C₂₀H₈N₄(C₆F₄O(CH₂)3NC₄H₄)3(C₆F₅)) 

Relevant academic research and scientific papers

Organic synthesis via magnetic attraction: Benign and sustainable protocols using magnetic nanoferrites

Magnetic nano-catalysts have been prepared using simple modification of iron ferrites. The nm size range of these particles facilitates the catalysis process, as an increased surface area is available for the reaction; the easy separation of the catalysts by an external magnet and their recovery and reuse are additional beneficial attributes. Glutathione bearing nano-ferrites have been used as organocatalysts for the Paal-Knorr reaction and homocoupling of boronic acids. Nanoferrites, post-synthetically modified by ligands, were used to immobilize nanometals (Cu, Pd, Ru, etc.) which enabled the development of efficient, sustainable and green procedures for azide-alkynes-cycloaddition (AAC) reactions, C-S coupling, O-allylation of phenol, Heck-type reactions and hydration of nitriles.

Magnetic Nanoparticle-Supported Glutathione as a Sustainable Organocatalyst

This invention relates to the use of nano-organocatalysts, and, more specifically, to the use of magnetic nanomaterial-supported organocatalysts. It is an object of the present invention to provide “green” catalysts and protocols. According to one embodiment of the invention, a nano-organocatalyst in the form of a magnetic nanomaterial-supported organocatalyst is provided. According to other embodiments of the invention, glutathione and cysteine are provided as organocatalysts and magnetic nanomaterial-supported glutathione and magnetic nanomaterial-supported cysteine are provided for use as nano-organocatalysts. According to another embodiment of the invention, a method of using a recyclable magnetic nanomaterial-supported organocatalyst using a totally benign aqueous protocol, without using any organic solvent in the reaction or during the workup, is provided. According to a further embodiment of the invention, a recyclable magnetic nanomaterial-supported organocatalyst for various organocatalytic reactions, including but not limited to Paal-Knorr reactions, aza-Michael addition and pyrazole synthesis, is provided.

Enantioselective Fujiwara-Moritani indole and pyrrole annulations catalyzed by chiral palladium(II)-NicOx complexes

The catalytic asymmetric Fujiwara-Moritani ring closures of several indole-and pyrrole-based cyclization precursors are reported. These unprecedented oxidative palladium(II)-catalyzed annulations allow for the formation of a stereogenic quaternary carbon atom, and decent levels of enantiocontrol are seen in 5-exo-trig cyclizations (54% ee for an indole and 76% ee for a pyrrole) while 6-exo-trig ring closures afford essentially racemic material. Novel oxazoline ligands with a nicotine platform (NicOx) are pivotal for good catalytic turnover as conventional PyOx ligands failed to produce acceptable chemical yields. The preparation of these NicOx ligands as well as the syntheses of the cyclization precursors are described in detail.

Nano-organocatalyst: magnetically retrievable ferrite-anchored glutathione for microwave-assisted Paal-Knorr reaction, aza-Michael addition, and pyrazole synthesis

Postsynthetic surface modification of magnetic nanoparticles by glutathione imparts desirable chemical functionality and enables the generation of catalytic sites on the surfaces of ensuing organocatalysts. In this article, we discuss the developments, unique activity, and high selectivity of nano-organocatalysts for microwave-assisted Paal-Knorr reaction, aza-Michael addition, and pyrazole synthesis. Their insoluble character coupled with paramagnetic nature enables easy separation of these nano-catalysts from the reaction mixture using external magnet, which eliminates the requirement of catalyst filtration.

Magnetic nanoparticle-supported glutathione: A conceptually sustainable organocatalyst

A conceptually novel nanoparticle-supported and magnetically recoverable organocatalyst has been developed, which is readily prepared from inexpensive starting materials in a truly sustainable manner; which catalyzes the Paal-Knorr reaction with high yield in pure aqueous medium that avoids the use of toxic organic solvents, even in the workup step.

Fused thiophone derivatives and drugs containing the same as the active ingredient

The present invention relates to a fused thiophene derivative of the formula (I) (wherein all the symbols are defined as described in the specification) and an inhibitor of producing interleukin-6 and/or interleukin-12 comprising the said derivative as an active ingredient.A fused thiophene derivative of the formula (I) is useful as an agent for the prevention and/or treatment of various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell carcinoma, Kaposi's sarcoma, rheumatoid arthritis, gammopathy, Castleman's disease, atrial myxoma, diabetes mellitus, autoimmune diseases, hepatitis, multiple sclerosis, colitis, graft versus host immune diseases, infectious diseases.

Synthesis and electropolymerisation of pyrrol-1-yl substituted phthalocyanines

2,9,16,23-Tetrakis(2-pyrrol-1-ylalkoxy)phthalocyanines, in which the phthalocyanine is connected via an alkylene spacer to a pyrrole substituent, are prepared via three steps in good yields. For the first time monomers with groups for electropolymerisatio

Synthesis of (R)-(-) and (S)-(+)-3-(1-pyrrolyl)propyl- N-(3,5- dinitrobenzoyl)-α-phenylglycinate and derivatives. A suitable chiral polymeric phase precursor

A synthetic route to obtain (R)-(-) (1), (S)-(+)-3-(1-pyrrolyl)propyl-N- (3,5-dinitrobenzoyl)-α-phenylglycinate (2) and derivatives is described. In a first step, pyrrole derivatives were prepared using the Clauson-Kaas method. The esterification, second step, was performed using basic conditions due to sensitivity of the pyrrole group toward acidic conditions. A tautomeric equilibrium involving the stereogenic center induces the product epimerization. The substitution of DMAP and Et3N by a highly hindered base, proton-sponge, furnished the final products without racemization. The ee of 1, 2 and of the corresponding methyl esters (3 and 4) were determined by 1H NMR analysis in the presence of optically active Eu(tfc)3. Epimerization was not observed in the preparation of the carboxylate salts (5-8).

Synthesis of Vitamin-B12 Derivatives with an Electropolymerizable Side Chain

Three new derivatives of vitamin B12 with a pyrrole head group attached to the corrin ring have been prepared. Ligand-exchange reactions and reduction provided reactive CoIII and CoII complexes. Their electrochemical properties and their potential for fixation at the surface of electrodes by electropolymerization were studied.

N-(HYDROXYALKYL) PYRROLES : PRECURSORS FOR THE SYNTHESIS OF POLYPYRROLES BEARING ACTIVE CENTRES.

N-(Hydroxyalkyl)pyrroles have been synthesized in good yields from halo-hydroxyalkanes and pyrrolyl potassium salt in DMSO-THF.These are compounds easy to handle and become precursors of specifically substituted pyrroles and polypyrroles.