1007834-63-0

Upstream product

• 4845-04-9 1-cyclohexene-1-methanol 
• 62-53-3 aniline 
• 32119-42-9 N-phenylcyclohex-1-enecarboxamide 
• 636-82-8 cyclohexene-1-carboxylic acid 
• 108-86-1 bromobenzene 
• 32917-19-4 cyclohex-1-en-1-ylmethylamine 
• 28075-50-5 cyclohex-1-en-1-yl trifluoromethane sulfonate 
• 103-01-5 N-Phenylglycine 
• 1192-88-7 1-cyclohexene-1-carboxaldehyde 
• 38127-47-8 2-bromocyclohex-1-ene-1-carbaldehyde 
• 201230-82-2 carbon monoxide 
• 121898-42-8 (2-Bromocyclohex-1-enyl)methyl bromide 
• 108-94-1 cyclohexanone 
• 117360-45-9 1-bromo-2-(hydroxymethyl)cyclohex-1-ene 

Downstream Products

• 138850-29-0 6'-methyl-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-amine 

Relevant academic research and scientific papers

PH-Mediated Selective Synthesis of N-Allylic Alkylation or N-Alkylation Amines with Allylic Alcohols via an Iridium Catalyst in Water

Amination of allylic alcohols is an effective approach in the facile synthesis of N-allylic alkylation or N-alkylation amines. Recently, a series of catalysts were devised to push forward this transformation. However, current synthetic methods are typical

Ligand-Controlled, Tunable Copper-Catalyzed Radical Divergent Trifluoromethylation of Unactivated Cycloalkenes

The Cu-catalyzed high-chemoselective trifluoromethylation reactions of unactivated cycloalkenes via the modulation of appropriate ligands have been explored. The Cu(I)/appropriate ligands-catalytic systems overcome the key challenge in differentiating two pathways involving radical intermediates and provide a ligand-controlled approach for site-specific spiro-aryltrifluoromethylation and chlorotrifluoromethylation to afford trifluoromethylated spiro-tetrahydroquinoline compounds and vicinal Cl-containing trifluoromethyl cycloalkanes. Moreover, compared with reported chlorine sources, 1,2-dichloroethane is used as more green and economical feedstock for chlorotrifluoromethylation. (Figure presented.).

Synthesis of Spiro-dihydroquinoline and Octahydrophenanthrene Derivatives via Palladium-Catalyzed Intramolecular Oxidative Arylation

A method for intramolecular sp2 C-H oxidative arylation of unactivated cyclic olefins has been developed to access spiro-dihydroquinoline and octahydrophenanthrene derivatives in a straightforward and efficient manner. Bearing picolinamide as a directing group, the alkenyl anilines cyclized to afford spiro-dihydroquinolines in moderate to excellent yields via direct oxidative arylation, while the alkenyl benzylamines furnished the octahydrophenanthrene derivatives in moderate yields via sequential oxidative arylation and double acetoxylation.

Decarboxylative Aminomethylation of Aryl- and Vinylsulfonates through Combined Nickel- and Photoredox-Catalyzed Cross-Coupling

A mild approach for the decarboxylative aminomethylation of aryl sulfonates by the combination of photoredox and nickel catalysis through C?O bond cleavage is described for the first time. A wide range of aryl triflates as well as aryl mesylates, tosylates and alkenyl triflates afford the corresponding products in good to excellent yields.

Aza-Wittig Rearrangements of N-Benzyl and N-Allyl Glycine Methyl Esters. Discovery of a Surprising Cascade Aza-Wittig Rearrangement/Hydroboration Reaction

Treatment of N-(arylmethyl)-N-aryl or N-allyl-N-aryl glycine methyl ester derivatives with nBu2BOTf and iPr2NEt effects an aza-Wittig rearrangement that provides N-aryl phenylalanine methyl ester derivatives and N-aryl allylglycine methyl ester derivatives, respectively, in good yield with moderate to good diastereoselectivity. Under similar conditions, analogous substrates bearing N-carbonyl groups are converted to 1,4,2-oxazaborole derivatives. Additionally, N-allyl-N-aryl glycine methyl ester derivatives subjected to similar conditions at elevated temperatures undergo an aza-[2,3]-Wittig rearrangement, followed by a subsequent hydroboration oxidation reaction, to afford substituted amino alcohol products.

Palladium-catalyzed carbonylative cyclization of 1-bromoallyl bromides with anilines leading to 1-aryl-1H-pyrrol-2(5H)-ones

1-Bromoallyl bromides are carbonylatively cyclized with anilines under carbon monoxide pressure in DMF in the presence of a catalytic amount of a palladium catalyst along with a base to give the corresponding 1-aryl-1H-pyrrol-2(5H)-ones in moderate to goo

Synthesis of cycloalkanoindoles, the carba analogs of physostigmine

The title compounds 9 were prepared by combined aza-Claisen rearrangement/intramolecular ring-closure reaction of N-allylaniline derivatives 3, followed by BBr3 mediated cleavage of methoxy group and subsequent formation of the phenylcarbamyl d