1007834-86-7Relevant academic research and scientific papers
Nickel-catalyzed Enantioselective Hydroarylation and Hydroalkenylation of Styrenes
Chen, Yue-Gang,Shuai, Bin,Xu, Xue-Tao,Li, Yi-Qian,Yang, Qi-Liang,Qiu, Hui,Zhang, Kun,Fang, Ping,Mei, Tian-Sheng
, p. 3395 - 3399 (2019)
We have developed a Ni-catalyzed enantioselective hydroarylation of styrenes with arylboronic acids using MeOH as the hydrogen source, providing an efficient method to access 1,1-diarylalkanes, which are essential structural units in many biologically active compounds. In addition, Ni-catalyzed enantioselective hydrovinylation of styrenes with vinylboronic acids is also realized with good yields and enantioselectivities. The synthetic utility was demonstrated by the efficient synthesis of (R)-(-)-ibuprofen.
A Cobalt-Catalyzed Enantioconvergent Radical Negishi C(sp3)-C(sp2) Cross-Coupling with Chiral MultidentateN,N,P-Ligand
Li, Zhuang,Cheng, Xian-Yan,Yang, Ning-Yuan,Chen, Ji-Jun,Tang, Wen-Yue,Bian, Jun-Qian,Cheng, Yong-Feng,Li, Zhong-Liang,Gu, Qiang-Shuai,Liu, Xin-Yuan
supporting information, p. 2215 - 2219 (2021/05/29)
A cobalt-catalyzed enantioconvergent radical Negishi C(sp3)-C(sp2) cross-coupling of racemic benzyl chlorides with arylzinc reagents has been developed in good yield with moderate enantioselectivities. This strategy provides an expedient access toward a range of enantioenriched 1,1-diarylmethanes. Key to this discovery is the utilization of a chiral multidentate anionicN,N,P-ligand to strongly coordinate with the cobalt catalyst and tune its chiral environment, thus achieving the enantiocontrol over the highly reactive prochiral alkyl radical species.
Enantioselective preparation of 1,1-diarylethanes: Aldehydes as removable steering groups for asymmetric synthesis
Fessard, Thomas C.,Andrews, Stephen P.,Motoyoshi, Hajime,Carreira, Erick M.
, p. 9331 - 9334 (2008/12/21)
Cut it out! Convenient procedures have been delineated for the synthesis of optically active, functionalized 1,1-diaryl-ethanes by decarbonylation of β,β-diaryl-propionaldehydes. The process can be conducted as a one-pot 1,4-addition/decarbonylation sequence. Aldehydes are used as removable steering groups in this new strategy for the preparation of optically active building blocks. (Chemical Equation Presented)
