1007834-86-7Relevant articles and documents
Nickel-catalyzed Enantioselective Hydroarylation and Hydroalkenylation of Styrenes
Chen, Yue-Gang,Shuai, Bin,Xu, Xue-Tao,Li, Yi-Qian,Yang, Qi-Liang,Qiu, Hui,Zhang, Kun,Fang, Ping,Mei, Tian-Sheng
, p. 3395 - 3399 (2019)
We have developed a Ni-catalyzed enantioselective hydroarylation of styrenes with arylboronic acids using MeOH as the hydrogen source, providing an efficient method to access 1,1-diarylalkanes, which are essential structural units in many biologically active compounds. In addition, Ni-catalyzed enantioselective hydrovinylation of styrenes with vinylboronic acids is also realized with good yields and enantioselectivities. The synthetic utility was demonstrated by the efficient synthesis of (R)-(-)-ibuprofen.
Enantioselective preparation of 1,1-diarylethanes: Aldehydes as removable steering groups for asymmetric synthesis
Fessard, Thomas C.,Andrews, Stephen P.,Motoyoshi, Hajime,Carreira, Erick M.
, p. 9331 - 9334 (2008/12/21)
Cut it out! Convenient procedures have been delineated for the synthesis of optically active, functionalized 1,1-diaryl-ethanes by decarbonylation of β,β-diaryl-propionaldehydes. The process can be conducted as a one-pot 1,4-addition/decarbonylation sequence. Aldehydes are used as removable steering groups in this new strategy for the preparation of optically active building blocks. (Chemical Equation Presented)