1007882-23-6Relevant articles and documents
Design and synthesis of imidazole N-H substituted amide prodrugs as inhibitors of hepatitis C virus replication
Zong, Xi,Cai, Jin,Chen, Junqing,Wang, Peng,Zhou, Gaoxin,Chen, Bo,Li, Wei,Ji, Min
, p. 3147 - 3150 (2015)
Abstract Twenty-five novel imidazole N-H substituted Daclatasvir (BMS-790052, DCV) analogues (8a-8y) were designed and synthesized as potential prodrugs. Structure modifications were performed in order to improve potency and pharmacokinetic (PK) properties. All target compounds were evaluated in a hepatitis C virus (HCV) genotype 1b replicon, and the 2-oxoethyl acetate substituted compound 8t showed similar anti-HCV activity (EC50 = 0.08 nM) to that of the lead compound Daclatasvir. Moreover, the utility of prodrug 8t was demonstrated through similar exposure of the parent compound when the prodrugs were dosed in vivo. PK studies showed that prodrug 8t was an ideal candidate for a slower and sustained release form of Daclatasvir.
MICRO-ELECTROLYSIS REACTOR FOR ULTRA FAST, OXIDANT FREE, C-C COUPLING REACTION AND SYNTHESIS OF DACLATASVIR ANALOGS THEREOF
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Paragraph 0164-0168, (2020/12/01)
The present invention relates to a continuous micro-electro-flow reactor system for ultra-fast, oxidant free, C—C coupling reaction for making symmetrical biaryls and analogs thereof. This invention further relates to the said process for preparation of antiviral drug, daclatasvir of general formula I.
PROCESS FOR PREPARATION OF DACLATASVIR AND SALTS
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Paragraph 0132, (2018/02/28)
The present invention relates to crystalline daclatasvir dihydrochloride hydrate and process for its preparation.
Anti-hepatitis C Daclatasvir synthesis method
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Paragraph 0089-0092, (2017/04/03)
The invention discloses an anti-hepatitis C Daclatasvir synthesis method. The anti-hepatitis C Daclatasvir synthesis method comprises the following steps that 1, 4,4'-di(2-chloracetyl) biphenyl and Boc-L-proline perform condensation to generate ester; 2,