1008-28-2

Usage

Uses

Used in Organic Synthesis:
4-Phenyl-5-methyloxazole is used as a key intermediate for the synthesis of various bioactive compounds and pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Pharmaceutical Research:
4-Phenyl-5-methyloxazole is utilized as a building block in the design and synthesis of novel pharmaceuticals, enhancing the discovery of potential therapeutic agents.
Used in Medicinal Chemistry:
4-Phenyl-5-methyloxazole is studied for its potential pharmacological properties, such as anticonvulsant and anxiolytic effects, making it a promising candidate for the treatment of neurological disorders.
Used in Antimicrobial Applications:
4-Phenyl-5-methyloxazole is investigated for its antimicrobial activities, offering a potential alternative for the development of new antimicrobial agents to combat drug-resistant infections.
Used in Antitumor Applications:
4-Phenyl-5-methyloxazole is explored for its antitumor activities, indicating its potential as a chemotherapeutic agent for the treatment of various types of cancer.

Upstream product

• 77287-34-4 formamide 
• 579-07-7 1-Phenylpropane-1,2-dione 
• 540-69-2 ammonium formate 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 23253-49-8 5-methyl-4-phenylisoxazole 
• 62921-45-3 3-phenyl-2-methyl-2H-azirine-2-carboxaldehyde 

Downstream Products

• 76162-97-5 5'-Methyl-6'-phenyl-[2,3']bipyridinyl 
• 100-47-0 benzonitrile 

Relevant academic research and scientific papers

Synthesis of azirines containing aldehyde functionality and their utilization as synthetic tools for five membered oxazoles and isoxazoles

(Chemical Equation Presented) A simple and useful procedure for the synthesis of azirines containing aldehyde functionality from open chain bromo/chloro-aldehydes at room temperature is reported. The scope of the ring expansion reaction of a number of 3-s

Photochemistry of 4- and 5- phenyl substituted isoxazoles

5-Phenylisoxazole (4) and 4-phenylisoxazole (22) underwent phototransposition to 5-phenyloxazole (5) and 4-phenyloxazole (24) respectively. Labeling with deuterium or methyl confirmed that these phototrans-positions occurred via the P4 pathway which involves only interchange of the N2 and C3 ring position. Thus, 4-deuterio-5-phenylisoxazole (4-4d), 4-methyl-5-phenylisoxazole (10), and 5-methyl-4-phenylisoxazole (23) phototransposed to 4-deuterio-5-phenyloxazole (5-4d), 4-methyl-5-phenyloxazole (11), and 5-methyl-4-phenyloxazole (25) respectively. In addition to phototransposition, isoxazoles 4, 10, and 23 also underwent photo-ring cleavage to yield benzoylacetonitrile (9), α-benzoylpropionitrile (15), and aceto-α-phenyl-acetonitrile (26) respectively. Irradiation of 5-phenyl-3-(trifluoromethyl)isoxazole (16) in acetonitrile led to 5-phenyl-2-(trifluoromethyl)oxazole (17), the P4 phototransposition product. Irradiation of 16 in methanol led to a substantial decrease in the yield of 17 and to the formation of a mixture of (E) and (Z)-2-methoxy-2- (trifluoromethyl)-3-benzoylaziridines 18a and 18b.