100800-51-9Relevant academic research and scientific papers
NH4I-Catalyzed Synthesis of Sulfonamides from Arylsufonylhydrazides and Amines
Yu, Hui,Zhang, Yonghao
, p. 359 - 362 (2016)
A novel and efficient approach to sulfonamides has been developed. Using TBHP as the oxidant and NH4I (20 mol%) as the catalyst, arylsulfonyl hydrazides reacted with amines to provide sulfonamides in moderate to good yields. Possible reaction pathway for the formation of the products was also discussed in this paper. Sulfonimides were synthesized through the oxidation coupling of arylsufonylhydrazides and amines by TBHP/NH4I system in moderate to good yields.
New adamantane phenylalkylamines with σ-receptor binding affinity and anticancer activity, associated with putative antagonism of neuropathic pain
Riganas, Stefanos,Papanastasiou, Ioannis,Foscolos, George B.,Tsotinis, Andrew,Serin, Guillaume,Mirjolet, Jean-Fran?ois,Dimas, Kostas,Kourafalos, Vassilios N.,Eleutheriades, Andreas,Moutsos, Vassilios I.,Khan, Humaira,Georgakopoulou, Stavroula,Zaniou, Angeliki,Prassa, Margarita,Theodoropoulou, Maria,Mantelas, Athanasios,Pondiki, Stavroula,Vamvakides, Alexandre
, p. 10241 - 10261 (2013/01/16)
The synthesis of the adamantane phenylalkylamines 2a-d, 3a-c, and 4a-e is described. These compounds exhibited significant antiproliferative activity, in vitro, against eight cancer cell lines tested. The σ1, σ2, and sodium channel binding affinities of compounds 2a, 3a, 4a, and 4c-e were investigated. The most interesting analogue, 4a, exhibited significant in vivo anticancer profile on pancreas, prostate, leukemia, and ovarian cancer cell line xenografts together with apoptosis and caspase-3 activation. Inhibition of the cancer cells cycle at the sub-G1 level was also obtained with 4a. Finally, encouraging results were observed with 4a in vivo on mice, suggesting putative antimetastatic and analgesic activities of this compound.
