1008131-75-6Relevant academic research and scientific papers
Synthesis of a ketomethylene isostere of the fibrillating peptide SNNFGAILSS
Mittag, Tina,Otzen, Daniel E.,Nielsen, Niels Chr.,Skrydstrup, Troels
supporting information; experimental part, p. 7955 - 7957 (2010/01/16)
(Chemical Equation Presented) The direct synthesis of a ketomethylene isostere of the fibril-forming decapeptide SNNFGAILSS is presented with the goal of understanding how small structural changes alter the ability of such peptides to recognize each other
Direct entry to peptidyl ketones via SmI2-mediated C-C bond formation with readily accessible N-peptidyl oxazolidinones
Mittag, Tina,Christensen, Kasper L.,Lindsay, Karl B.,Nielsen, Niels Christian,Skrydstrup, Troels
, p. 1088 - 1092 (2008/09/18)
(Chemical Equation Presented) In this work, a new method for the preparation of peptidyl ketones is presented employing a SmI2/H 2O-mediated coupling of N-peptidyl oxazolidinones with electron-deficient alkenes. The requisite peptide
