100827-79-0

Usage

Chemical Properties

Yellow Solid

InChI:InChI=1/C17H15BrClNO4S/c1-24-15(22)7-6-10-8-12(17(25-10)20-14(21)9-18)16(23)11-4-2-3-5-13(11)19/h2-5,8H,6-7,9H2,1H3,(H,20,21)

Upstream product

• 598-21-0 2-Bromoacetyl bromide 
• 100827-77-8 2-amino-3-(2-carbomethoxyethyl)-6-(2-chlorobenzoyl)thiophene 
• 19515-61-8 diethyl 2-(3-oxo-propyl)malonate 
• 40018-25-5 2-Chlorobenzoyl acetonitrile 
• 100827-76-7 diethyl 2-[[5-amino-4-(2-chlorobenzoyl)-thien-2-yl]methyl]malonate 
• 100827-78-9 3-(5-amino-4-(2-chlorobenzoyl)thiophen-2-yl)propionic acid 

Downstream Products

• 100827-83-6 2-(2-carbomethoxyethyl)-4-(2-chlorophenyl)-9-methyl-6H-thieno-<3,2-f><1,2,4>triazolo-<4,3-a><1,4>-diazepine 
• 100826-98-0 2-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-ethane-1-carboxylic acid 
• 100827-84-7 3-[5-(2-Chloro-phenyl)-2-hydrazono-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-7-yl]-propionic acid methyl ester 
• 100827-82-5 7-(2-carbomethoxyethyl)-5-(2-chlorophenyl)-1H-thieno<2,3-e>-1,4-diazepine-2-thione 
• 100827-80-3 7-(2-carbomethoxyethyl)-5-(2-chlorophenyl)-1H-thieno<2,3-e>-1,4-diazepin-2-one 
• 100827-81-4 2-Aminoacetylamino-3-o-chlorobenzoyl-5-(2-carbomethoxyethyl)thiophene 

Relevant academic research and scientific papers

Thieno-1,4-diazepines

The invention relates to new thieno-1,4-diazepines of general formula STR1 wherein R1, R2, R3, R°, R', Z, X, Y and n have the meanings given in the specification. The new compounds are intended to be used in the treatment of pathological conditions and diseases in which PAF (platelet activating factor) is implicated.

Thieno-traizolo-1,4-diazepino-2-carboxylic acid amides

The invention relates to new thieno-traizolo-1,4-diazepino-2-carboxylic acid amides of formula I STR1 wherein R 1 represents hydrogen, a C 1 -C 4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably Cl or Br, or by hydroxy, cyclopropyl, C 1 -C 3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;R 2 and R 3, each independently, represent hydrogen, a C 1 -C 4 straight-chained or branched alkyl, C 1 -C 4 hydroxyalkyl or the two groups R 2 and R 3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C 1 -C 4 alkyl, preferably a methyl group;R 4 represents alpha-pyridyl or a phenyl in which the phenyl ring can be substituted preferably in the 2-position, by methyl, halogen, preferably chlorine or bromine, nitro or trifluoromethyl;n represents one of the numbers 0, 1, 2, 3, 4, 5, 6, 7 or 8; and novel intermediates therefor.The compounds of formula I are useful in the treatment of pathological conditions and diseases in which platelet activating factor is implicated.

Brotizolam radioimmunoassay: Development, evaluation, and application to human plasma samples

A radioimmunoassay for the determination of the hypnotic agent brotizolam (11) was developed. With this procedure, an antiserum was used which was obtained from rabbits immunized with the hapten 10 (We 934) covalently bound to serum albumin and tritium-la