100827-81-4

Basic information

• Product Name: 2-Aminoacetylamino-3-o-chlorobenzoyl-5-(2-carbomethoxyethyl)thiophene
• Synonyms: 2-Aminoacetylamino-3-o-chlorobenzoyl-5-(2-carbomethoxyethyl)thiophene
• CAS NO: 100827-81-4
• Molecular Weight: 380.852
• Mol File: 100827-81-4.mol

Chemical Properties

• CAS DataBase Reference: 2-Aminoacetylamino-3-o-chlorobenzoyl-5-(2-carbomethoxyethyl)thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Aminoacetylamino-3-o-chlorobenzoyl-5-(2-carbomethoxyethyl)thiophene(100827-81-4)
• EPA Substance Registry System: 2-Aminoacetylamino-3-o-chlorobenzoyl-5-(2-carbomethoxyethyl)thiophene(100827-81-4)

Safety Data

• Hazardous Substances Data: 100827-81-4(Hazardous Substances Data)

Upstream product

• 100827-76-7 diethyl 2-[[5-amino-4-(2-chlorobenzoyl)-thien-2-yl]methyl]malonate 
• 100827-77-8 2-amino-3-(2-carbomethoxyethyl)-6-(2-chlorobenzoyl)thiophene 
• 100827-78-9 3-(5-amino-4-(2-chlorobenzoyl)thiophen-2-yl)propionic acid 
• 40018-25-5 2-Chlorobenzoyl acetonitrile 
• 19515-61-8 diethyl 2-(3-oxo-propyl)malonate 
• 100827-79-0 2-bromoacetylamino-6-(2-carbomethoxyethyl)-3-(2-chlorobenzoyl)thiophene 

Downstream Products

• 100827-80-3 7-(2-carbomethoxyethyl)-5-(2-chlorophenyl)-1H-thieno<2,3-e>-1,4-diazepin-2-one 
• 100827-82-5 7-(2-carbomethoxyethyl)-5-(2-chlorophenyl)-1H-thieno<2,3-e>-1,4-diazepine-2-thione 
• 100827-84-7 3-[5-(2-Chloro-phenyl)-2-hydrazono-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-7-yl]-propionic acid methyl ester 
• 100826-98-0 2-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-ethane-1-carboxylic acid 
• 100827-83-6 2-(2-carbomethoxyethyl)-4-(2-chlorophenyl)-9-methyl-6H-thieno-<3,2-f><1,2,4>triazolo-<4,3-a><1,4>-diazepine 

Relevant articles and documents

Thieno-traizolo-1,4-diazepino-2-carboxylic acid amides

The invention relates to new thieno-traizolo-1,4-diazepino-2-carboxylic acid amides of formula I STR1 wherein R 1 represents hydrogen, a C 1 -C 4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably Cl or Br, or by hydroxy, cyclopropyl, C 1 -C 3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;R 2 and R 3, each independently, represent hydrogen, a C 1 -C 4 straight-chained or branched alkyl, C 1 -C 4 hydroxyalkyl or the two groups R 2 and R 3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C 1 -C 4 alkyl, preferably a methyl group;R 4 represents alpha-pyridyl or a phenyl in which the phenyl ring can be substituted preferably in the 2-position, by methyl, halogen, preferably chlorine or bromine, nitro or trifluoromethyl;n represents one of the numbers 0, 1, 2, 3, 4, 5, 6, 7 or 8; and novel intermediates therefor.The compounds of formula I are useful in the treatment of pathological conditions and diseases in which platelet activating factor is implicated.

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