100836-99-5Relevant academic research and scientific papers
Chromatography-free enzymatic kinetic resolution of secondary alcohols
Maywald, Matthias,Pfaltz, Andreas
, p. 3654 - 3660 (2009)
Racemic secondary alcohols were resolved by enzymatic esterification using Candida antarctica lipase B (CAL B). After derivatization of the unreacted enantiomer with phthalic anhydride, the resulting phthalic acid monoesters could be easily separated from the corresponding acetates by precipitation and filtration or distillation, thus avoiding laborious column chromatography, which is a major obstacle for large-scale reactions. This method has been successfully applied to the multigram synthesis of enantiopure pyridyl alcohols.
Use of (S)-α-methylbenzylamine in the resolution of racemic 2-octanol and α-methylbenzyl alcohol
Reyes,Juaristi
, p. 1053 - 1058 (2007/10/02)
The title chiral amine can be a convenient substitute for brucine or strychnine in Ingersoll's classical method for the resolution of alcohols via fractional crystallization of their diastereoisomeric phthalate salts.
OPTICAL YIELD AND STEREOSELECTIVITY IN KINETIC RESOLUTION REACTIONS
Potapov, V. M.,Dem'yanovich, V. M.,Khlebnikov, V. A.,Korovina, T. G.
, p. 759 - 762 (2007/10/02)
The stereoselectivity of the acylation of 1-phenylethanol by phthalic anhydride in the presence of (S)-dimethyl(1-phenylethyl)amine at the initial stage of the reaction is approximately twice the stereoselectivity at 50percent conversion of the initial alcohol.
