1008750-58-0

Basic information

• Product Name: a-D-Mannopyranoside, phenyl 3-O-[(4-Methoxyphenyl)Methyl]-4,6-O-[(R)-(4-Methoxyphenyl)Methylene]-2-O-(phenylMethyl)-1-thio-
• Synonyms: a-D-Mannopyranoside, phenyl 3-O-[(4-Methoxyphenyl)Methyl]-4,6-O-[(R)-(4-Methoxyphenyl)Methylene]-2-O-(phenylMethyl)-1-thio-
• CAS NO: 1008750-58-0
• Molecular Formula: C35H36O7S
• Molecular Weight: 600.72114
• Mol File: 1008750-58-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: a-D-Mannopyranoside, phenyl 3-O-[(4-Methoxyphenyl)Methyl]-4,6-O-[(R)-(4-Methoxyphenyl)Methylene]-2-O-(phenylMethyl)-1-thio-(CAS DataBase Reference)
• NIST Chemistry Reference: a-D-Mannopyranoside, phenyl 3-O-[(4-Methoxyphenyl)Methyl]-4,6-O-[(R)-(4-Methoxyphenyl)Methylene]-2-O-(phenylMethyl)-1-thio-(1008750-58-0)
• EPA Substance Registry System: a-D-Mannopyranoside, phenyl 3-O-[(4-Methoxyphenyl)Methyl]-4,6-O-[(R)-(4-Methoxyphenyl)Methylene]-2-O-(phenylMethyl)-1-thio-(1008750-58-0)

Safety Data

• Hazardous Substances Data: 1008750-58-0(Hazardous Substances Data)

Upstream product

• 808761-99-1 phenyl 4,6-O-p-methoxybenzylidene-1-thio-α-D-mannopyranoside 
• 1008750-57-9 phenyl 3-O-p-methoxybenzyl-4,6-O-p-methoxybenzylidene-1-thio-α-D-mannopyranoside 
• 100-39-0 benzyl bromide 
• 824-94-2 p-methoxybenzyl chloride 

Relevant articles and documents

Structure-Activity relationship studies on acremomannolipin A, the potent calcium signal modulator with a novel glycolipid structure 4: Role of acyl side chains on d-mannose

As part of an ongoing study on the structure-Activity relationship of acremomannolipin A (1)-the novel glycolipid isolated from Acremonium strictum possessing potent calcium signal-modulating activity-the role of acyl substituents on the d-mannose moiety was examined. Three partially deacylated homologs (2a-2c) and 20 homologs (2d-2w) bearing different acyloxy side chains were synthesized via the stereoselective β-mannosylation of appropriately protected mannosyl sulfoxides (3) with d-mannitol derivatives (4), and their calcium signal-modulating activities were examined. The activities of 2a-2c were completely lost. Homologs bearing relatively short acyloxy groups at C-3, C-4, and C-6 positions (2t-2v) exhibited less activity than 1, whereas a heptanoyl homolog (2w: C7) maintained activity nearly equal to that of 1. When the acyl groups at these three positions were substituted by an octanoyl group (2i: C8), the activity was completely lost. On the other hand, of the 10 homologs in which the octanoyl at C-2 was substituted by other acyloxy moieties (2j-2s), three (2m: C7, 2n: C9, 2o: C10) maintained potent activity. These results suggested that peracylated mannose structure is critical for calcium signal-modulating activity, and this activity is precisely dependent on the length of four acyl side chains on d-mannose.