1009630-86-7Relevant academic research and scientific papers
FLT3 INHIBITORS AND USES THEREOF
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Paragraph 00651; 00655, (2014/12/12)
The present invention provides methods of using compounds of formula I: or compositions thereof for the inhibition of FLT3, and the treatment of FLT3-mediated disorders.
CDK8 INHIBITORS AND USES THEREOF
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Paragraph 00424, (2014/12/12)
The present invention provides methods of using compounds of formula I: and compositions thereof for the inhibition of CDK8, and the treatment of CDK8-mediated disorders.
Synthesis of the perdeuterated cellulose solvents N-methylmorpholine N-oxide (NMMO-d11) and N,N-dimethylacetamide (DMAC-d9)
Adelwoehrer, Christian,Yoneda, Yuko,Nakatsubo, Fumiaki,Rosenau, Thomas
, p. 28 - 32 (2008/09/18)
The synthesis of the perdeuterated cellulose solvents NMMO-d11 (9) and N,N-dimethylacetamide-d9 (14) is described. NMMO-d 11 was obtained according to a five-step approach from non-labeled diglycolic acid (1) via diethylene glycole-d8 (4) and its bis-tosylate (5), which underwent cyclization with benzylamine to N-benzylmorpholine (6). The removal of the benzyl protecting group, methylation and N-oxidation completed the synthesis. DMAc-d9 (14) was obtained from deuterated acetic acid (10) and dimethylamine-carbon dioxide complex (17) with acidic alumina as the catalyst according to a solvent-free gas-solid reaction. Copyright
New deuterated oligo(ethylene glycol) building blocks and their use in the preparation of surface active lipids possessing labeled hydrophilic tethers
Faragher, Robert J.,Schwan, Adrian L.
, p. 1371 - 1378 (2008/04/12)
(Chemical Equation Presented) For the introduction of additional analysis protocols of tethered molecules, a method is presented to prepare functionalized, deuterated oligo(ethylene glycols) from ethylene glycol-d 4. Partial oligomerization of ethylene glycol-d4 and conversion to ditosylates is accompanied by coupling reactions to prepare doubly benzyl protected oligo(ethylene glycols) with two to five repeating units. The tetramer bearing 16 deuteria was elaborated at both ends to eventually prepare 2,3-di-O-phytanyl-sn-glycerol-1-tetraethylene glycol-D,L-α-lipoic acid ester (DPTL), which bears a fully deuterated tetra(ethylene glycol) spacer group. Through linking of functionalized components, an analogue of DPTL possessing an octa(ethylene glycol) spacer group was prepared, both in deuterated and unlabeled form.
