1009806-75-0Relevant academic research and scientific papers
Idotrimethylsilane and catalytic iodine promoted cyclization for the facile synthesis for the facile synthesis of 3-monoarylated five-membered benzosultams
Dong, Yue-Hui,Ni, Qiong-Wei,Ma, Shu-Tao,Liu, Zhao-Peng
experimental part, p. 637 - 648 (2010/09/07)
3-Monoarylated five-membered benzosultams with various functional groups were prepared by simple and convenient two-step procedures. N-t-Bu-benzenesulfonamides were lithiated and reacted with substituted aromatic aldehydes to form the corresponding carbinols, which were converted to the cyclic compounds via a sequence of consecutive processes mediated by TMSCl-NaI-MeCN reagent and catalytic amount of iodine. Iodine played a crucial role in the eliminating the reductive side reaction in the cyclization processes.
