100992-42-5Relevant academic research and scientific papers
Complete deracemization by attrition-enhanced Ostwald ripening elucidated
Noorduin, Wim L.,Meekes, Hugo,Van Enckevort, Willem J. P.,Millemaggi, Alessia,Leeman, Michel,Kaptein, Bernard,Kellogg, Richard M.,Vlieg, Elias
supporting information; experimental part, p. 6445 - 6447 (2009/03/11)
(Chemical Equation Presented) Shaken and stirred: The emergence of single chirality in the solid state during grinding of a slurry has been kinetically studied for a phenylglycine amide (see scheme). The insight obtained into the underlying process of attrition-enhanced Ostwald ripening enables the definition of suitable conditions to increase the deracemization rate drastically.
Amide Bond Replacements: Incorporation of a 2,5,5-Trisubstituted Imidazoline into Dipeptides and into a CCK-4 Derivative.
Gilbert, Ian,Rees, David C.,Richardson, Reginald S.
, p. 2277 - 2280 (2007/10/02)
Synthetic methodology for the introduction of a 2,5,5-trisubstituted imidazoline ring as an amide replacement into dipeptide derivatives of Phe, Trp, Lys(N6-CBZ) and Nle is described.This replacement is also incorporated into the Trp-Nle bond o
N-SUBSTITUTED AMINO ACID DERIVATIVES WITH HYPERALPHALIPOPROTEINAEMIC ACTIVITY
Baggaley, Keith H.,Fears, Robin,Ferres, Harry,Geen, Graham R.,Hatton, Ian K.,et al.
, p. 523 - 532 (2007/10/02)
A series of N-substituted amino acid derivatives was synthesized and the compounds were evaluated for their effects on serum total cholesterol, HDL cholesterol and triglycerides in experimental animals.Hyperalphalipoproteinaemic activity was found for some of these compounds tested, especially BRL 26314 (2) and related 3-aryl-2-aminopropionic acids.Structure-activity relationships are discussed.Keywords: N-substituted amino acid derivatives / hyperalphalipoproteinaemic activity
