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1010-53-3

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1010-53-3 Usage

Description

3-Phenylthiazolidine-2,4-dione, also known as phenylthiazolidinedione or glitazone, is a chemical compound that belongs to the thiazolidinedione class of drugs. It is characterized by its ability to increase the sensitivity of the body's cells to insulin, thereby enhancing glucose uptake and utilization. 3-phenylthiazolidine-2,4-dione also contributes to the reduction of glucose production in the liver and has been investigated for its potential anti-inflammatory and anti-cancer properties.

Uses

Used in Pharmaceutical Industry:
3-Phenylthiazolidine-2,4-dione is used as an oral antidiabetic medication for the treatment of type 2 diabetes. It functions by improving the body's insulin sensitivity, which aids in better glucose uptake and utilization, and by reducing glucose production in the liver.
Used in Research and Development:
3-Phenylthiazolidine-2,4-dione is utilized in scientific research for its potential anti-inflammatory and anti-cancer properties. Studies are conducted to explore its therapeutic potential in various conditions beyond diabetes, including inflammatory and neoplastic diseases.
However, it is important to note that the use of 3-phenylthiazolidine-2,4-dione is associated with several side effects, such as weight gain, fluid retention, and an increased risk of heart failure. These potential cardiovascular risks have led to controversy surrounding its use in the treatment of type 2 diabetes.

Check Digit Verification of cas no

The CAS Registry Mumber 1010-53-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,1 and 0 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1010-53:
(6*1)+(5*0)+(4*1)+(3*0)+(2*5)+(1*3)=23
23 % 10 = 3
So 1010-53-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H7NO2S/c11-8-6-13-9(12)10(8)7-4-2-1-3-5-7/h1-5H,6H2

1010-53-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-phenyl-1,3-thiazolidine-2,4-dione

1.2 Other means of identification

Product number -
Other names 3-phenyl-2,4-dioxotetrahydrothiazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1010-53-3 SDS

1010-53-3Relevant articles and documents

Design, synthesis and biological evaluation of N-substituted indole-thiazolidinedione analogues as potential pancreatic lipase inhibitors

George, Ginson,Auti, Prashant S.,Paul, Atish T.

, p. 49 - 59 (2021)

Pancreatic Lipase (PL) is a key enzyme responsible for the digestion of 50%–70% of dietary triglycerides, hence its inhibition is considered as a viable approach for the management of obesity. A series of indole-TZD hybrid analogues were synthesized, characterized and evaluated for their PL inhibitory activity. Knoevenagel condensation of various substituted indole-3-carboxaldehyde with substituted thiazolidinediones resulted in the formation of titled analogues. Analogues 6d and 6e exerted potent PL inhibitory activity (IC50-6.19 and 8.96?μM, respectively). Further, these analogues exerted a competitive mode of PL inhibition. Moreover, molecular modelling studies were in agreement with the in vitro results (Pearson's r?=.8682, p?.05). The fluorescence spectroscopic analysis further supported the strong binding affinity of these analogues with PL. A molecular dynamics study (20?ns) indicated that these analogues were stable in a dynamic environment. Thus, the present study highlighted the potential role of indole-thiazolidinedione hybrid analogues as potential PL inhibitors and further optimization might result in the development of new PL inhibitory lead candidates.

Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity

Oppermann, Sina,Schrader, Florian C.,Els?sser, Katharina,Dolga, Amalia M.,Kraus, Anna Lena,Doti, Nunzianna,Wegscheid-Gerlach, Christof,Schlitzer, Martin,Culmsee, Carsten

, p. 273 - 289 (2014/08/18)

Mitochondrial demise is a key feature of progressive neuronal death contributing to acute and chronic neurological disorders. Recent studies identified a pivotal role for the BH3-only protein B-cell lymphoma-2 interacting domain death antagonist (Bid) for such mitochondrial damage and delayed neuronal death after oxygen-glucose deprivation, glutamate-induced excitotoxicity, or oxidative stress in vitro and after cerebral ischemia in vivo. Therefore, we developed new N-phenyl-substituted thiazolidine-2,4-dione derivatives as potent inhibitors of Bid-dependent neurotoxicity. The new compounds 6, 7, and 16 were identified as highly protective by extensive screening in a model of glutamate toxicity in immortalized mouse hippocampal neurons (HT-22 cells). These compounds significantly prevent truncated Bid-induced toxicity in the neuronal cell line, providing strong evidence that inhibition of Bid was the underlying mechanism of the observed protective effects. Furthermore, Bid-dependent hallmarks of mitochondrial dysfunction, such as loss of mitochondrial membrane potential, ATP depletion, as well as impairments in mitochondrial respiration, are significantly prevented by compounds 6, 7, and 16. Therefore, the present study identifies a class of N-phenyl thiazolidinediones as novel Bid-inhibiting neuroprotective agents that provide promising therapeutic perspectives for neurodegenerative diseases, in which Bid-mediated mitochondrial damage and associated intrinsic death pathways contribute to the underlying progressive loss of neurons. Copyright

Ionic liquid-accelerated N-arylation of 5-arylidene-2,4-thiazolidinediones with diaryliodonium salts

Yang, De-Hong,Gao, Hong-Liang,Yang, Ben-Yong,Chen, Zhen-Chu

experimental part, p. 686 - 687 (2009/09/06)

An efficient method for the synthesis of N-aryl-5-arylidene-2,4- thiazolidinediones has been developed involving the N-arylation of 5-arylidene-2,4-thiazolidinediones derivatives with diaryliodonium salts in the ionic liquid [bmim]PF6 (1-butyl-

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