101020-89-7Relevant articles and documents
Novel spirobicyclic artemisinin analogues (artemalogues): Synthesis and antitumor activities
Liu, Gang,Song, Shanshan,Shu, Shiqi,Miao, Zehong,Zhang, Ao,Ding, Chunyong
, p. 17 - 28 (2015)
The sesquiterpene lactone framework of artemisinin was used as a drug repositioning prototype for the development of novel antitumor drugs. Several series of novel artemisinin analogues (artemalogues) were designed and synthesized through 1,3-dipolar cycloaddition of artemisitene with nitrile oxides or nitrones. The isoxazolidine-containing spirobicyclic artemalogue 11b turns out to be the most potent with low micromolar IC50 values against all three tumor cells, which were at least 4-to 14-fold more potent than the parent artemisinin.
Anti-proliferative and anti-malarial activities of spiroisoxazoline analogues of artemisinin
Pratap, Surya,Naaz, Fatima,Reddy, Srinivas,Jha, Kunal K.,Sharma, Kalicharan,Sahal, Dinakar,Akhter, Mymoona,Nayakanti, Devanna,Kumar, Halmuthur M. S.,Vandana,Pandey, Kailash,Shafi, Syed
, (2019)
A series of spiroisoxazoline analogues of artemisinin was synthesized by employing 1,3-dipolar cycloaddition between various in situ generated nitrile oxides and artemisitene. All the synthesized compounds were tested for their anti-proliferative and anti
[...] and Isoxazolidine substituted artemisinin derivatives, preparation method and application thereof (by machine translation)
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Paragraph 0160, (2017/07/20)
The invention provides a [...] and Isoxazolidine substituted artemisinin derivatives, its preparation method and application, in particular, the invention provides a compound of formula I is shown. Wherein the definition of each group as described in the
