154698-10-9 Usage
General Description
(+)-9-Norartemisinin, 9-n-butyl- is a chemical compound that is a derivative of artemisinin, a natural product known for its potent antimalarial properties. (+)-9-Norartemisinin, 9-n-butyl-, with a butyl group attached to the 9th carbon atom, has been studied for its potential as an antimalarial agent. It is structurally related to artemisinin and its derivatives, which are widely used in the treatment of malaria. Research on (+)-9-Norartemisinin, 9-n-butyl- has shown promising results in inhibiting the growth of malaria parasites and in some cases showed improved efficacy compared to other artemisinin derivatives. The compound's antimalarial activities make it a potential candidate for further drug development and research in the fight against malaria.
Check Digit Verification of cas no
The CAS Registry Mumber 154698-10-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,6,9 and 8 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 154698-10:
(8*1)+(7*5)+(6*4)+(5*6)+(4*9)+(3*8)+(2*1)+(1*0)=159
159 % 10 = 9
So 154698-10-9 is a valid CAS Registry Number.
154698-10-9Relevant articles and documents
C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene
Ekthawatchai,Kamchonwongpaisan,Kongsaeree,Tarnchompoo,Thebtaranonth,Yuthavong
, p. 4688 - 4695 (2001)
Nucleophilic additions of lithium keto and ester enolates and mono- and bifunctional Grgnard reagents to artemisitene provided C-16-derived artemisinin monomers, dmers, trimers, and tetramers whose antimalarial and cytotoxic have been evaluated.
Structure-Activity Relationships of the Antimalarial Agent Artemisinin. 1. Synthesis and Comparative Molecular Field Analysis of C-9 Analogs of Artemisinin and 10-Deoxoartemisinin
Avery, Mitchell A.,Gao, Fenglan,Chong, Wesley K. M.,Mehrotra, Sanjiv,Milhous, Wilbur K.
, p. 4264 - 4275 (2007/10/02)
A series of C-9 β-substituted artemisinin analogs (2-21) were synthesized via dianion alkylation of the total synthetic intermediate 57 followed by subsequent ozonolysis/acidification, or by alkylation of the enolate derived from (+)-9-desmethylartemisini
