1273599-65-7Relevant articles and documents
Divergent Synthetic Route to Oxidized Benzofulvene Sesquiterpenoids: Protecting-Group-Free Total Synthesis of Nicotianasesterpenes A, B, and a Polygonum Sesquiterpenoid
Jeong, Myeonggyo,Lee, Hyunkee,Kim, Gibeom,Jo, Jeyun,Chang, Jae Won,Jung, Jee H.,Suh, Young-Ger,Yun, Hwayoung
, p. 6714 - 6719 (2019)
A divergent approach toward the protecting-group-free total synthesis of oxidized benzofulvene sesquiterpenoids is described. Highlight of our synthesis includes regio- and stereoselective assembly of the common intermediate 9 by the orchestrated application of a Pd(0)-catalyzed reductive dehalogenation, a solvent-free methylenation, and a vinylogous Stork enamine aldol condensation in a substrate-controlled manner. The advanced intermediate 9 was efficiently transformed to nicotianasesterpenes A, B, and a polygonum sesquiterpenoid, respectively.