1011-26-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-chlorobutyrophenone is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new compounds with specific therapeutic properties, contributing to the advancement of medicine.
Used in Organic Synthesis:
In the field of organic chemistry, 2-bromo-4-chlorobutyrophenone is used as a building block for the creation of new organic compounds. Its versatility in forming different chemical structures makes it a valuable asset in research and development, leading to the discovery of novel compounds with potential applications in various industries.
Used in Research and Development:
2-Bromo-4-chlorobutyrophenone is employed as a key component in the development of new compounds with specific properties and functions. Its unique structure and reactivity make it an essential tool in the hands of researchers, who utilize it to explore new chemical pathways and create innovative products.

Upstream product

• 108-90-7 chlorobenzene 
• 4981-63-9 4-n-butanoylchlorobenzene 

Downstream Products

• 696613-64-6 2-[1-(4-bromo-phenyl)-2-(4-chloro-benzoyl)-butyl]-malonic acid dimethyl ester 
• 123979-03-3 1-(4-chlorophenyl)-1,2-propanedione dioxime 
• 948908-05-2 (Z)-1-(4-chlorophenyl)-2-hydroxyamino-1-hydroxyiminopropane 
• 119313-12-1 2-benzyl-2-(dimethylamino)-1-(4-morpholinophenyl)-butan 1-one 

Relevant academic research and scientific papers

Design, synthesis and broad-spectrum Bcr-Abl inhibitory activity of novel thiazolamide-benzamide derivatives

Bcr-Abl plays an important role in the pathogenesis and development of chronic myeloid leukemia (CML). But Bcr-Abl is prone to mutation, so it increases the difficulty of clinical treatment. Therefore, it is crucial to design a new class of broad-spectrum Bcr-Abl inhibitors. Herein, forty novel thiazolamide-benzamide derivatives were synthesized and evaluated their broad-spectrum Bcr-Abl inhibitory activities. The newly synthesized compounds were characterized by using spectrum data (1H NMR, APCI-MS and IR) and elemental analysis. The protein kinase results indicated that eight compounds (3a, 3e, 3m, 3n, 3p, 4c, 4f, 4g) showed high activities to wild-type and T315I mutation. The most potent compound 3m exhibited an Abl IC50 value as low as 1.273 μM and showed inhibition to the T315I mutant with IC50 value 39.89 μM. 3m could prove to be a new promising lead compound for the further development of broad-spectrum Bcr-Abl inhibitors to overcome clinical acquired resistance.

Synthetic method of 2-benzyl-2-dimethylamino-1-(4-morpholinophenyl) butanone

The invention discloses a synthetic method of 2-benzyl-2-dimethylamino-1-(4-morpholinophenyl) butanone. The synthetic method comprises the following steps: (1) carrying out a Friedel-Crafts reaction on chlorobenzene with n-butyryl chloride under the catalysis of aluminium trichloride to obtain a compound I; (2) carrying out a bromination reaction on the compound I with bromine under the action ofa catalytic oxidizing agent to obtain a compound II; (3) carrying out a substitution reaction on the compound II with dimethylamine to obtain a compound III; (4) carrying out a quaternization reactionon the compound III with benzyl chloride to obtain a compound IV; (5) carrying out a substitution reaction on the compound IV with morpholine under the action of a composite catalyst to obtain a compound V; and (6) carrying out a rearrangement reaction on the compound V under the action of an alkali so as to obtain the 2-benzyl-2-dimethylamino-1-(4-morpholinophenyl) butanone. The synthetic methodprovided by the invention has the advantages of mild technological condition, simple operation, high selectivity and high total yield.

A new amino ketone photoinitiator and in UV - LED light curing system application (by machine translation)

The invention provides a method suitable for UV - LED light source setting new amino ketone photo initiator, can in long wave zone (365 - 395 nm) has stronger absorption, UV - LED light source is suitable for curing, has overcome the traditional cured high energy consumption, pollution and shortcomings. Electronic unlocalized is good, with strong intramolecular electron transfer performance and excellent photoelectric nature, in the long-wave region 365 nm - 395 nm range have strong absorption, is suitable for high-power UVLED ultraviolet light curing system, compared with the prior art such optical initiator has a considerable advantage. (by machine translation)

COMPOUND FOR INHIBITING TYROSINE KINASE ACTIVITY OF DDR2 PROTEIN

A new furopyrimidine compound, their pharmaceutically acceptable salt, and a tyrosine kinase activity inhibitor. The furopyrimidine compound is a compound defined by chemical formula 1, 2, 3 or 4, on their precursor, and can exist as a form of free base or in an acid-addition salt. Since the furopyrimidine compound has an effect of inhibiting activity of DDR2 tyrosine kinase, it can be used in treating illnesses caused by the DDR2 tyrosine kinase activity such as hepatocirrhosis, rheumatoid arthritis or cancer.

Antifungal azole compounds

This invention relates to novel antifungal azole compound of the formula: STR1 wherein X and Y are CH or N, R1 is optionally substituted phenyl or phenylalkyl, 1-6C alkyl or 3-8C cycloalkyl, R2 and R3 are hydrogen or 1-6C alkyl, and R4 and R5 are hydrogen, NH2, 1-6C alkyl, alkoxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylamino or alkenyl wherein each alkyl, alkoxy or alkenyl part is of 1-6C, phenyl, phenyl-(1-6C)-alkyl, phenoxy-(1-6C)-alkyl or phenyl-(2-6C)-alkenyl in which the phenyl may be optionally substituted, or a heterocyclyl, (heterocyclyl)-(1-6C)-alkyl or (heterocyclyl)-(2-6C)-alkenyl in each of which the heterocyclyl ring may be optionally substituted, provided at least one of R2, R3, R4 and R5 is other than hydrogen, and the acid addition salts of those compounds which contain a basic nitrogen; together with processes for their manufacture; compositions containing them; and a method of combatting plant fungal diseases.