1011484-23-3

Basic information

• Product Name: 6-fluoro-3-Methyl-1H-Indole
• Synonyms: 6-fluoro-3-Methyl-1H-Indole;1H-INDOLE, 6-FLUORO-3-METHYL-;6-fluoro-3-methylindole
• CAS NO: 1011484-23-3
• Molecular Formula: C₉H₈FN
• Molecular Weight: 149.1649232
• Mol File: 1011484-23-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-fluoro-3-Methyl-1H-Indole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-3-Methyl-1H-Indole(1011484-23-3)
• EPA Substance Registry System: 6-fluoro-3-Methyl-1H-Indole(1011484-23-3)

Safety Data

• Hazardous Substances Data: 1011484-23-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 399-51-9 6-fluoro-1H-indole 
• 2795-41-7 6-fluoro-1H-indole-3-carbaldehyde 
• 107-11-9 1-amino-2-propene 
• 202865-72-3 1-bromo-4-fluoro-2-iodobenzene 

Downstream Products

• 1428236-55-8 C₂₀H₁₈FNO₃ 

Relevant articles and documents

Constructing Saturated Guanidinum Heterocycles by Cycloaddition of N-Amidinyliminium Ions with Indoles

We report that structurally complex guanidinium heterocycles can be prepared in one step by regio- and stereoselective [4 + 2]-cycloadditions of N-amidinyliminium ions with indoles or benzothiophene. In contrast to reactions of these heterodienes with alkenes, density functional theory (DFT) calculations show that these cycloadditions take place in a concerted asynchronous fashion. The [4 + 2]-cycloaddition of N-amidinyliminium ions (1,3-diaza-1,3-dienes) with indoles and benzothiophene are distinctive, as related [4 + 2]-cycloadditions of N-acyliminium ions (1-oxa-3-aza-1,3-dienes) are apparently unknown.

N-Alkylation-Initiated Redox-Neutral [5 + 2] Annulation of 3-Alkylindoles with o-Aminobenzaldehydes: Access to Indole-1,2-Fused 1,4-Benzodiazepines

Described herein is an unprecedented N-Alkylation-initiated redox-neutral [5 + 2] annulation of 3-Alkylindoles with o-Aminobenzaldehydes via a cascade N-Alkylation/dehydration/[1,5]-hydride transfer/Friedel-Crafts alkylation sequence. A series of indole-1,2-fused 1,4-benzodiazepines are facilely constructed in moderate to good yields in one step. This protocol features excellent regioselectivity, metal-free conditions, high step economy, and wide substrate scope.

Methylation of C(sp3)-H/C(sp2)-H bonds with methanol catalyzed by cobalt system

A highly efficient Co-based catalytic system, composed of a commercially available Co salt, a tetradentate phosphine ligand P-(CH2CH2PPh2)3(PP3), and a base (denoted as [Co]/PP3/base), is developed for the methylation of C(sp3)-H and C(sp2)-H bonds using methanol as a methylating reagent. The Co(BF4)2.6H2O/PP3/K2CO3 catalytic system showed high catalytic activity for the methylation of C-H bonds in aryl alkyl ketones, aryl acetonitriles, and indoles, with wide substrate scope and good functional group tolerance, and methylsubstituted products were obtained in good to excellent yields at 100 °C. This cheap, readily available, and highly efficient Co-based catalytic system may have promising applications in methylation reaction using methanol.