101167-08-2Relevant academic research and scientific papers
Nickel(II)-Catalyzed Synthesis of Sulfinates from Aryl and Heteroaryl Boronic Acids and the Sulfur Dioxide Surrogate DABSO
Lo, Pui Kin Tony,Chen, Yiding,Willis, Michael C.
, p. 10668 - 10673 (2019/11/11)
We report a redox-neutral Ni(II)-catalyzed sulfination of readily available aryl and heteroaryl boronic acids. Using the combination of commercially available, air-stable NiBr2·(glyme), a commercially available phenanthroline ligand, and DABSO, boronic acids are efficiently converted to the corresponding sulfinate salts, which can be further elaborated to valuable sulfonyl-containing groups, including sulfones, sulfonamides, sulfonyl fluorides, and sulfonate esters. The catalyst loading can be reduced to 2.5 mol ?% on a gram scale. This practically simple protocol tolerates an unprecedented range of pharmaceutically relevant and electron-poor (hetero)aryl boronic acids, allowing the direct synthesis of active pharmaceutical ingredients.
Palladium-Catalyzed Synthesis of (Hetero)Aryl Alkyl Sulfones from (Hetero)Aryl Boronic Acids, Unactivated Alkyl Halides, and Potassium Metabisulfite
Shavnya, Andre,Hesp, Kevin D.,Mascitti, Vincent,Smith, Aaron C.
supporting information, p. 13571 - 13575 (2015/11/16)
A palladium-catalyzed one-step synthesis of (hetero)aryl alkyl sulfones from (hetero)arylboronic acids, potassium metabisulfite, and unactivated or activated alkylhalides is described. This transformation is of broad scope, occurs under mild conditions, and employs readily available reactants. A stoichiometric experiment has led to the isolation of a catalytically active dimeric palladium sulfinate complex, which was characterized by X-ray diffraction analysis.
PHENOXY ACETIC ACID DERIVATIVES
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Page/Page column 114-115, (2010/09/03)
The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.
ELECTRONIC EFFECTS IN ALKYL 4-CHLOROPHENYL SULFONE AND SULFOXIDE MOLECULES ACCORDING TO 35Cl NQR DATA
Feshin, V. P.,Voronkov, M. G.,Dolgushin, G. V.,Romanenko, L. S.,Aliev, I. A.,Mirzoeva, M. A.
, p. 1103 - 1106 (2007/10/02)
Compounds of the 4-ClC6H4S(O)CHn.(CH3)3-n and 4-ClC6H4SO2R series nH and CHn(CH3)3-n> were synthesized and studied by the 35Cl NQR method.It was found that their NQR frequencies change regularly with increase in the number n.
