1012367-41-7

Basic information

• Product Name: tert-butyl-(R)-(1-(4-methoxybenzyloxy)pent-4-en-2-yloxy)dimethylsilane
• Synonyms: tert-butyl-(R)-(1-(4-methoxybenzyloxy)pent-4-en-2-yloxy)dimethylsilane
• CAS NO: 1012367-41-7
• Molecular Weight: 336.547
• Mol File: 1012367-41-7.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl-(R)-(1-(4-methoxybenzyloxy)pent-4-en-2-yloxy)dimethylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl-(R)-(1-(4-methoxybenzyloxy)pent-4-en-2-yloxy)dimethylsilane(1012367-41-7)
• EPA Substance Registry System: tert-butyl-(R)-(1-(4-methoxybenzyloxy)pent-4-en-2-yloxy)dimethylsilane(1012367-41-7)

Safety Data

• Hazardous Substances Data: 1012367-41-7(Hazardous Substances Data)

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 80910-01-6 (R)-2-(((4-methoxybenzyl)oxy)methyl)oxirane 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 194342-84-2 (R)-1-[(4-methoxybenzyl)oxy]pent-4-en-2-ol 

Downstream Products

• 1012367-24-6 C₂₈H₄₁NO₇SSi 
• 1450806-67-3 N-[(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-phenylhex-5-en-2-yl]-2-methylpropane-2-sulfinamide 
• 127041-77-4 ((1S,2R)-1-Benzyl-2-hydroxy-pent-4-enyl)-carbamic acid benzyl ester 
• 174623-89-3 ((1S,2R)-1-Benzyl-2-methoxymethoxy-pent-4-enyl)-methyl-carbamic acid benzyl ester 

Relevant articles and documents

Total Synthesis of Kalimantacin A

The kalimantacins make up a family of hybrid polyketide-nonribosomal peptide-derived natural products that display potent and selective antibiotic activity against multidrug resistant strains of Staphylococcus aureus. Herein, we report the first total synthesis of kalimantacin A, in which three fragments are prepared and then united via Sonogashira and amide couplings. The enantioselective synthetic approach is convergent, unlocking routes to further kalimantacins and analogues for structure-activity relationship studies and clinical evaluation.

A highly stereoselective formal synthesis of hapalosin

A flexible and highly diastereoselective formal synthesis of hapalosin, a cyclodepsipeptide isolated from the blue green alga Hapalosiphon welwitschii and having multidrug-resistance-reversing activity is described. The synthetic route involves the addition of organometallic reagent to N-tert- butanesulfinylimine, Jung nonaldol aldol reaction, and Yamaguchi esterification as key steps. Georg Thieme Verlag Stuttgart · New York.