1012367-43-9Relevant articles and documents
Total synthesis of dinophysistoxin-2 and 2-epi-dinophysistoxin-2 and their PPase inhibition
Pang, Yucheng,Fang, Chao,Twiner, Michael J.,Miles, Christopher O.,Forsyth, Craig J.
supporting information; experimental part, p. 7631 - 7635 (2011/10/01)
The first total syntheses of the title compounds highlight novel assemblies of the C1-C14 and C28-C38 domains, including an unexpected diastereoselectivity in the Sharpless asymmetric dihydroxylation of an alkene at C1iC2. PPase inhibition assays revealed that 2-epi-DTX-2 is at least 1 to 2 orders of magnitude less potent than DTX-2, thus indicating that the configuration at C2 in DTX-2 is crucial for potent inhibition (see picture). Copyright
A stereoselective approach for the total synthesis of clonostachydiol
Yadav,Swamy,Subba Reddy
scheme or table, p. 2773 - 2776 (2009/04/16)
A stereoselective synthesis of clonostachydiol is accomplished using readily available (±)-epichlorohydrin as a precursor. The synthesis involves direct and straightforward reactions such as Sharpless asymmetric epoxidation, iodination, stereoselective op
Synthesis of the DE-ring of goniodomin A and prediction of its natural relative stereochemistry
Katagiri, Takahiro,Fujiwara, Kenshu,Kawai, Hidetoshi,Suzuki, Takanori
, p. 233 - 237 (2008/03/30)
Goniodomin A (1) was first isolated from Alexandrium hiranoi as a stereochemically unidentified antifungal agent in 1987 by Murakami. In this study, two stereoisomeric series of non-macrocyclic and macrocyclic DE-ring model compounds of 1 were synthesized
