10128-60-6

Basic information

• Product Name: 2H-1,3-Oxazine-2,4(3H)-dione, 3,6-dimethyl-
• CAS NO: 10128-60-6
• Molecular Formula: C6H7NO3
• Molecular Weight: 141.126
• Mol File: 10128-60-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-1,3-Oxazine-2,4(3H)-dione, 3,6-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,3-Oxazine-2,4(3H)-dione, 3,6-dimethyl-(10128-60-6)
• EPA Substance Registry System: 2H-1,3-Oxazine-2,4(3H)-dione, 3,6-dimethyl-(10128-60-6)

Safety Data

• Hazardous Substances Data: 10128-60-6(Hazardous Substances Data)

Upstream product

• 107292-92-2 N-acetoacetyl-N-methylurethane 

Downstream Products

• 138395-61-6 1-benzyl-3,6-dimethyl-2,4-pyrimidinedione 
• 19674-60-3 3,6-dimethyluracil 
• 13509-52-9 1,3,6-trimethyluracil 
• 20306-75-6 N-methylacetoacetamide 
• 127085-38-5 (E)-3-methoxy-N-methylbut-2-enamide 
• 91305-83-8 3-acetyl-4-amino-1-methyl-1H-pyrrole-2,5-dione 
• 91305-82-7 5-imino-1,4-dimethyl-1,5-dihydro-2H-pyrrol-2-one 
• 135678-98-7 (E)-3-Phenylsulfanyl-but-2-enoic acid methylamide 
• 76889-80-0 3,6-dimethyl-1-(γ-hydroxypropyl)uracil 
• 63550-50-5 1-(3-bromoprop-1-y)-3,6-dimethyluracil 
• 591-60-6 butyl acetoacetate 
• 2308-18-1 isoamyl acetoacetate 
• 16695-54-8 1-(morpholin-4-yl)butane-1,3-dione 
• 126401-65-8 N-methyl-(4-morpholine)carboxamide 

Relevant articles and documents

SYNTHESIS OF 5,5'-METHYLENEBISPYRIMIDINE DERIVATIVES AND 3,4-DITHIA(6.1)(1.5) PYRIMIDINOPHANE

Convenient syntheses of 3,6-dimethyl-1,3-oxazine-2,4(3H)-dione (3) and 5,5'-methylenebis(1-(2-hydroxyethyl)-3,6-dimethyl-2,4(1H,3H)-pyrimidinedione (5) are described.Compound 3 was prepared by the reaction of N-methylurethane with diketene, followed by alkali treatment, and 5 was obtained by treatment of 1-(2-hydroxyethyl)-3,6-dimethyl-2,4(1H,3H)-pyrimidinedione (4) with paraformaldehyde and hydrochloric acid in quantitative yield.Bromination of 5 was carried out with 47percent hydrobromic acid to give 5,5'-methylenebis(1-(2-bromoethyl)-3,6-dimethyl-2,4(1H,3H)-pyrimidinedione) (6).The reaction of 6 with thiourea afforded 7 and subsequent treatment of 7 with sodium hydroxide gave 5,5'-methylenebis(1-(2-mercaptoethyl)-3,6-dimethyl-2,4(1H,3H)-pyrimidinedione) (9).Compound 9 was oxidized to 8,11,15,18-tetramethyl-3,4-dithia(6.1)(1.5)-1,2,3,4-tetrahydro-2,4-dioxopyrimidinophane (10) with iodine under conditions of high dilution.Keywords: methylenebispyrimidine; dithiapyrimidinophane; 1,3-oxazine-2,4-dione; ring transformation; diketene; N-methylurethane; N-acetoacetyl-N-methylurethane.