20306-75-6Relevant articles and documents
PHOTOCHEMISTRY OF 4(3H)-PYRIMIDIN-4-ONES. FORMATION OF MEDIUM-RING LACTAMS
Hirai, Yoshiro,Yamazaki, Takao,Hirokami, Shun-ichi,Nagata, Masanori
, p. 3067 - 3070 (1980)
Upon irradiation, 4(3H)-pyrimidin-4-one(1) afforded a di-imine derivate(2), which, when hydrolyzed in an acidic methanol solution, gave N-methyl acetoacetamide(3).On the other hand, the fused 4(3H)-pyrimidin-4-ones, (4) and (5), gave medium ring lactams (6) and (7), which were hydrolyzed in an acidic methanol solution to give (8) and (9), respectively.
Asymmetric Synthesis of α,β-Epoxy-?-lactams through Tandem Darzens/Hemiaminalization Reaction
Shen, Bin,Liu, Wen,Cao, Weidi,Liu, Xiaohua,Feng, Xiaoming
supporting information, p. 4713 - 4716 (2019/06/27)
A catalytic asymmetric tandem Darzens/hemiaminalization reaction of glyoxals with α-bromo-β-esteramides or α-bromo-β-ketoamide was accomplished in the presence of a chiral N,N′-dioxide/Yb(III) complex. Various chiral α,β-epoxy-?-lactams were obtained in moderate to good yields with excellent diastereo- and enantioselectivities. The versatility of the transformation is illustrated in the formal synthesis of berkeleyamide D.
A convenient method for reduction dehalogenation of α-halocarbonyl compounds using benzenethiol in K+/CH3CN system
Dong, Wei-Li,Cai, Wen-Xi,Wu, Rui,Li, Zheng-Ming,Zhao, Wei-Guang,Liu, Xing-Hai
, p. 980 - 983 (2016/07/06)
Benzenethiol, as a reductive agent for the dehalogenation of various α-halocarbonyl compounds, is investigated in the K+/CH3CN system. The reaction affords the reduced compounds in high yields under mild reaction conditions, especially α-chlorocarbonyl compounds. Furthermore, the reaction performed under ultrasonic irradiation greatly shortens the reaction time.