10128-72-0

Basic information

• Product Name: METHYL 3-HYDROXYISONICOTINATE
• Synonyms: METHYL 3-HYDROXYISONICOTINATE;3-Hydroxypyridine-4-carboxylic acid methyl ester;4-Pyridinecarboxylicacid, 3-hydroxy-, methyl ester;Methyl 3-hydroxyisonicotinate ,95%;3-Hydroxy-4-pyridinecarboxylic acid methyl ester;Methyl3-hydroxypyridine-4-carboxylate;Methyl 3-hydroxypyridine-4-carboxylate, 4-(Ethoxycarbonyl)-3-hydroxypyridine
• CAS NO: 10128-72-0
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• Product Categories: pharmacetical
• Mol File: 10128-72-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 74-76°
• Boiling Point: 313.557 °C at 760 mmHg
• Flash Point: 143.434 °C
• Appearance: /
• Density: 1.287
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 6.92±0.10(Predicted)
• CAS DataBase Reference: METHYL 3-HYDROXYISONICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-HYDROXYISONICOTINATE(10128-72-0)
• EPA Substance Registry System: METHYL 3-HYDROXYISONICOTINATE(10128-72-0)

Safety Data

• Statements: 20/22
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 10128-72-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C7H7NO3/c1-11-7(10)5-2-3-8-4-6(5)9/h2-4,9H,1H3

Upstream product

• 55279-30-6 methyl 3-aminoisonicotinate 
• 67-56-1 methanol 
• 10128-71-9 3-hydroxyisonicotinic acid 

Downstream Products

• 33349-67-6 3-Hydroxy-4-hydroxymethyl-pyridin 
• 88394-01-8 isonicotinoylhydrazide 
• 1461603-32-6 methyl 3-[(4-phenylbutyl)oxy]-4-pyridinecarboxylate 
• 89640-77-7 3,N-dihydroxy-isonicotinamide 
• 102074-60-2 4-(hydroxymethyl)-3-methoxypyridine 
• 59786-32-2 methyl 3-methoxy-4-pyridinecarboxylate 

Relevant articles and documents

Intramolecular hydrogen bonding of o-hydroxyesters and related compounds evaluated by deuterium isotope effects on 13C chemical shifts and principal component analysis

o-Hydroxyaromatic esters, β-hydroxyketoesters, Meldrums acids, other o-hydroxyesters and a few o-hydroxyacid anhydrides are investigated by deuterium isotope effects on 13C chemical shifts, xΔC(OD). Especially the ester carbons show unusual deuterium isotope effects. A principal component analysis based on bond lengths and distances around the hydrogen bond six-membered ring make it possible to predict isotope effects. The ratio nΔC{double bond, long}O(OD)/2ΔC(OD) can be used to predict the extent of transmission via the hydrogen bond. Furthermore, deuterium isotope effects can be used to gauge possible tautomerism.

SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION

Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.