59786-32-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Methoxypyridine-4-carboxylic acid methyl ester is used as a pharmaceutical intermediate for the synthesis of various active ingredients. Its unique chemical structure allows it to be incorporated into the development of new drugs, enhancing their efficacy and therapeutic potential.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Methoxypyridine-4-carboxylic acid methyl ester is utilized as a building block in the creation of new agrochemical products. Its properties contribute to the development of innovative solutions for crop protection and pest management, improving agricultural productivity and sustainability.
Used in Material Science:
3-Methoxypyridine-4-carboxylic acid methyl ester may have applications in material science, where its chemical properties can be leveraged to develop new materials with specific characteristics. Its potential use in this field highlights the compound's versatility and its ability to contribute to advancements in various industries.
Used in Organic Chemistry:
As an organic compound, 3-Methoxypyridine-4-carboxylic acid methyl ester plays a role in organic chemistry, where it can be used in various chemical reactions and processes. Its presence in this field underscores the importance of understanding and utilizing its properties to drive innovation and progress in chemical research and development.

InChI:InChI=1/C8H9NO3/c1-11-7-5-9-4-3-6(7)8(10)12-2/h3-5H,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 10128-72-0 methyl 3-hydroxypyridine-4-carboxylate 
• 67-56-1 methanol 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 654663-32-8 3-methoxypyridine-4-carboxylic acid 
• 10128-71-9 3-hydroxyisonicotinic acid 
• 82673-73-2 3-amino-5-methoxypyridine-4-carboxylic acid 
• 77903-35-6 3-Methoxy-5-(pivaloylamino)pyridine-4-carboxylic Acid 
• 124-41-4 sodium methylate 
• 103698-10-8 methyl 3-nitropyridine-4-carboxylate 
• 82673-74-3 methyl 3-amino-5-methoxypyridine-4-carboxylate 

Downstream Products

• 102074-60-2 4-(hydroxymethyl)-3-methoxypyridine 
• 83431-02-1 1-(3-methoxypyridin-4-yl)-ethanone 
• 30152-05-7 1-(3-hydroxypyridin-4-yl)ethan-1-one 
• 83431-06-5 3-methylisooxozolo<5,4-c>pyridine 

Relevant academic research and scientific papers

Nucleophilic aromatic substitution of methyl 3-nitropyridine-4-carboxylate

The nitro group of methyl 3-nitropyridine-4-carboxylate (1) has successfully been replaced by nitrogen, oxygen and sulphur nucleophiles by nucleophilic aromatic substitution to give the 3-azido, 3-methoxy, 3-phenoxy and 3-thiophenoxypyridine-4-carboxylate

ATMOSPHERE DEPENDENT PHOTOREACTION OF METHYL 4-PYRIDINECARBOXYLATE IN METHANOL. METHOXYLATION AT 3-POSITION UNDER O2 AND METHOXYLATION AND HYDROXYMETHYLATION AT 2-POSITION UNDER N2

The UV-Irradition of methyl 4-pyridinecarboxylate in methanol under oxygen in the presence of H2SO4 brings about methoxylation at the 3-position of the pyridine ring, while under nitrogen methoxylation and hydroxymethylation occur at the 2-position.

Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

Nature routinely engages alcohols as leaving groups, as DNA biosynthesis relies on the removal of water from ribonucleoside diphosphates by a radical-mediated "spin-center shift" (SCS) mechanism. Alcohols, however, remain underused as alkylating agents in synthetic chemistry due to their low reactivity in two-electron pathways. We report herein an enantioselective α-benzylation of aldehydes using alcohols as alkylating agents based on the mechanistic principle of spin-center shift. This strategy harnesses the dual activation modes of photoredox and organocatalysis, engaging the alcohol by SCS and capturing the resulting benzylic radical with a catalytically generated enamine. Mechanistic studies provide evidence for SCS as a key elementary step, identify the origins of competing reactions, and enable improvements in chemoselectivity by rational photocatalyst design.

Atmosphere Dependent Photoreaction of 4-Pyridinecarboxylic Ester in Acidic Methanolic Solutions

The UV-irradiation of methyl 4-pyridinecarboxylate (1) in methanol under oxygen in the presence of sulfuric acid brings about methoxylation at the 3-position of the pyridine ring, while under nitrogen methoxylation and hydroxymethylation occur at the 2-position.The change of photoreactions of 1 caused by oxygen can not be explained either by the promotion of intersystem crossing by O2 or by the charge transfer interactions between 1 and O2.

Synthetic Application of Lithiation Reactions: A Convenient Synthesis of 3,4-Dihydro-5-hydroxycarbostyril, 1,2,3,4-Tetrahydro-5-hydroxy-2-oxo-1,7-naphthyridine, and Methyl 3-Methoxypyridine-4-carboxylate

3,4-Dihydro-5-hydroxycarbostyril (3), a key intermediate for a clinically used β-receptor blocking agent (1), and its 7-aza analog (4) were prepared by an acid-catalyzed cyclization of the N-pivaloylamino-esters (17 and 19), which were obtained by using o