101342-40-9Relevant academic research and scientific papers
Isobutyraldehyde in the synthesis of isopropyl-substituted 4H-pyrans, 1,4-dihydropyrano[2,3-c]pyrazole, 1,4-dihydropyridines, and cyclobutane
Dyachenko,Chernega
, p. 952 - 960 (2005)
Condensation of isobutyraldehyde with CH acids, such as acetoacetanilide, dimedone, acetoacetamide, ethyl benzoylacetate, resorcinol, cyanoacetic acid, malononitrile, 3-methyl-1-ethyl-2-pyrazolin-5-one, benzoylacetone, and cyanoacetamide, in the presence of amines gave isopropyl-substituted 4H-pyrans, 1,4-dihydropyrano[2,3-c]pyrazole, 4H-benzo[b]pyranes, 1,4-dihydropyridines, and 1,1-dicyano-2-(1-cyano-1-ethoxycarbonyl)methyl-4-isopropyl-3, 3-dimethylcyclobutane. The structure of the latter product was studied by X-ray diffraction analysis.
Dibutylamine-catalysed efficient one-pot synthesis of biologically potent pyrans
Kalla, Reddi Mohan Naidu,Kim, Mi Ri,Kim, Il
supporting information, p. 717 - 720 (2015/01/30)
An expedient, eco-friendly and efficient procedure for the preparation of novel pyran derivatives has been developed through a solvent-free, one-pot reaction of various aldehydes, malononitrile and either methylacetoacetate or ethyl benzoylacetate in the presence of dibutylamine (2.5 mol %) at room temperature. This procedure is advantageous because it is mild, environmentally friendly, gives high yields and requires short reaction times. Furthermore, the product did not necessitate separation via extraction and column chromatography.
