101375-34-2Relevant academic research and scientific papers
Preparation method of halogenated alkyl-2, 3-dihydro-1H-indole-5-alcohol
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, (2022/04/06)
The invention provides a preparation method of halogenated alkyl-2, 3-dihydro-1H-indole-5-ol, which comprises the following steps: by taking a compound I as a raw material, carrying out Friedel-Crafts acylation reaction on the compound I under the action of Lewis acid to generate a compound II, then obtaining an alkene compound III under the environmental conditions of an acetic anhydride acylation reagent and hexamethylenetetramine, and finally obtaining the halogenated alkyl-2, 3-dihydro-1H-indole-5-ol. The compound III is subjected to concentrated sulfuric acid cyclization to obtain a compound IV, and the compound IV is subjected to electrophilic electron-deficient effect reduction, hydrogenation reduction, halogenation reaction and methyl reduction under strong acid to obtain a compound VII, namely the halogenated alkyl-2, 3-dihydro-1H-indole-5-alcohol. According to the present invention, the condensed ring benzofuran main body compound is obtained by using the Sonogashira coupling and the ring closing reaction of the halogenated phenol and the corresponding terminal alkyne so as to avoid the property defects of the benzofuran liquid crystal compound;
