101444-54-6

Basic information

• Product Name: N-benzyl-2-phenyl-1,3-oxazole-4-carboxamide
• Synonyms: N-benzyl-2-phenyl-1,3-oxazole-4-carboxamide
• CAS NO: 101444-54-6
• Molecular Formula: C₁₇H₁₄N₂O₂
• Molecular Weight: 278.30526
• Mol File: 101444-54-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-benzyl-2-phenyl-1,3-oxazole-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-phenyl-1,3-oxazole-4-carboxamide(101444-54-6)
• EPA Substance Registry System: N-benzyl-2-phenyl-1,3-oxazole-4-carboxamide(101444-54-6)

Safety Data

• Hazardous Substances Data: 101444-54-6(Hazardous Substances Data)

Upstream product

• 1204-70-2 2-phenyl-1,3-oxazole-4-carbonyl chloride 
• 100-46-9 benzylamine 
• 609366-75-8 (S)-benzyl 2-phenyl-4,5-dihydrooxazole-4-carboxylate 
• 138739-05-6 2-benzoylamino-3-hydroxypropionic acid benzyl ester 
• 98-88-4 benzoyl chloride 
• 855405-22-0 benzyl 2-phenyloxazole-4-carboxylate 
• 23012-16-0 2-phenyl-1,3-oxazole-4-carboxylic acid 
• 1284215-38-8 C₁₇H₁₆N₂O₂ 

Relevant articles and documents

Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds

Tuberculosis (TB) is a devastating disease resulting in a death every 20 s. Thus, new drugs are urgently needed. Herein we report ten classes of compounds - oxazoline, oxazole, thiazoline, thiazole, pyrazole, pyridine, isoxazole, imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine and imidazo[1,2-c]pyrimidine - which have good (micromolar) to excellent (sub-micromolar) antitubercular potency. The 5,6-fused heteroaromatic compounds were the most potent with MIC's as low as 37Rv, clinically relevant drug sensitive, multi- and extensively resistant Mtb strains as well as having good in vitro metabolic stability.