23012-16-0

Basic information

• Product Name: 2-Phenyl-1,3-oxazole-4-carboxylic acid
• Synonyms: 2-phenyloxazole-4-carboxylic acid;4-Carboxy-2-phenyl-1,3-oxazole;4-Oxazolecarboxylicacid, 2-phenyl-;2-Phenyl-1,3-oxazole-4-carboxylic acid
• CAS NO: 23012-16-0
• Molecular Formula: C₁₀H₇NO₃
• Molecular Weight: 189.17
• Product Categories: Oxazoles, Isoxazoles & Benzoxazoles;Carboxylic Acids;Oxazoles, Isoxazoles & Benzoxazoles;Carboxylic Acids
• Mol File: 23012-16-0.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 396.4 °C at 760 mmHg
• Flash Point: 193.5 °C
• Appearance: /
• Density: 1.32 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Phenyl-1,3-oxazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-1,3-oxazole-4-carboxylic acid(23012-16-0)
• EPA Substance Registry System: 2-Phenyl-1,3-oxazole-4-carboxylic acid(23012-16-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 23012-16-0(Hazardous Substances Data)

Usage

General Description

2-Phenyl-1,3-oxazole-4-carboxylic acid is a chemical compound with the molecular formula C10H7NO3. It is a heterocyclic compound containing a five-membered oxazole ring with a phenyl group and a carboxylic acid functional group attached. 2-Phenyl-1,3-oxazole-4-carboxylic acid has been studied for its potential pharmaceutical applications, including as an anti-inflammatory and antibacterial agent. It is also used in organic synthesis as a building block for the preparation of various bioactive molecules. The properties and potential uses of 2-Phenyl-1,3-oxazole-4-carboxylic acid make it an important compound in medicinal and chemical research.

Upstream product

• 59171-72-1 2-phenyl-oxazole-4-carboxylic acid methyl ester 
• 100-52-7 benzaldehyde 
• 55-21-0 benzamide 
• 609366-75-8 (S)-benzyl 2-phenyl-4,5-dihydrooxazole-4-carboxylate 
• 138739-05-6 2-benzoylamino-3-hydroxypropionic acid benzyl ester 
• 98-88-4 benzoyl chloride 
• 138478-13-4 isopropyl N-benzoylaziridine-2-carboxylate 
• 37592-54-4 isopropyl 2-phenyl-4,5-dihydro-1,3-oxazole-4-carboxylate 
• 55044-06-9 methyl 2-phenyl-2-oxazoline-4-carboxylate 
• 20989-42-8 N-benzoylserine methyl ester 
• 1113-59-3 bromopyruvic acid 
• 91349-15-4 2-benzoylamino-3-chloro-acrylic acid methyl ester 
• 39819-39-1 2-phenyl-oxazole-4-carboxylic acid ethyl ester 

Downstream Products

• 132198-53-9 2-phenyl-5H-[1,3]oxazolo[4,5-c]quinolin-4-one 
• 101444-54-6 N-benzyl-2-phenyloxazole-4-carboxamide 

Relevant articles and documents

Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors

In this present study, a series of 5-phenyl-2-furan and 4-phenyl-2-oxazole derivatives were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. In vitro results showed that the synthesized compounds exhibited considerable inhibitory ac

Towards New Tricyclic Motifs: Intramolecular C–H Arylation as the Key Step in a Formal [3+3] Cyclocondensation Strategy

Tricyclic scaffolds structurally related to the well-known benzodiazepine class of drugs show diverse biological activities strikingly different from those of their benzodiazepine counterparts. Interested by this scaffold-hopping perspective, we previousl

Design, synthesis and biological evaluation of 2,4-disubstituted oxazole derivatives as potential PDE4 inhibitors

In this study, a series of pyrazole derivatives containing 4-phenyl-2-oxazole moiety were designed and synthesized in a concise way, some of which exhibited considerable inhibitory activity against PDE4B and blockade of LPS-induced TNF-α release. Compound