101445-48-1

Upstream product

• 1138-14-3 1,3-bis(2-thienyl)-1,3-propanedione 
• 100-63-0 phenylhydrazine 
• 16753-14-3 1-phenyl-3,5-di(thiophen-2-yl)-1H-pyrazoline 
• 88-15-3 2-Acetylthiophene 
• 98-03-3 thiophene-2-carbaldehyde 
• 2309-48-0 1,3-di(thiophen-2-yl)propenone 

Relevant academic research and scientific papers

Iron-catalyzed aerobic oxidative aromatization of 1,3,5-trisubstituted pyrazolines

A simple and high yielding method for the synthesis of tri-substituted pyrazoles via iron(III) catalyzed aerobic oxidative aromatization of pyrazolines has been reported. The process demonstrates a variety of functional group tolerance.

Synthesis of tri- and tetrasubstituted pyrazoles via Ru(II) catalysis: Intramolecular aerobic oxidative C-N coupling

An unprecedented ruthenium(II)-catalyzed intramolecular oxidative C-N coupling method has been developed for the facile synthesis of a variety of synthetically challenging tri- and tetrasubstituted pyrazoles. Dioxygen gas is employed as the oxidant in this transformation. The reaction demonstrates excellent reactivity, functional group tolerance, and high yields.