1014645-83-0

Basic information

• Product Name: Benzoic acid, 4-(1-aminocyclopropyl)-, hydrochloride (1:1)
• Synonyms: Benzoic acid, 4-(1-aminocyclopropyl)-, hydrochloride (1:1);CASUFMKTHYLTHT-UHFFFAOYSA-N
• CAS NO: 1014645-83-0
• Molecular Formula: C₁₀H₁₁NO₂*ClH
• Molecular Weight: 213.66078
• Mol File: 1014645-83-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoic acid, 4-(1-aminocyclopropyl)-, hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(1-aminocyclopropyl)-, hydrochloride (1:1)(1014645-83-0)
• EPA Substance Registry System: Benzoic acid, 4-(1-aminocyclopropyl)-, hydrochloride (1:1)(1014645-83-0)

Safety Data

• Hazardous Substances Data: 1014645-83-0(Hazardous Substances Data)

Upstream product

• 1014645-75-0 4-(1-aminocyclopropyl)benzonitrile 

Downstream Products

• 1014645-87-4 methyl 4-(1-aminocyclopropyl)benzoate hydrochloride 
• 1006037-03-1 4-(1-aminocyclopropyl)-benzoic acid methyl ester 

Relevant articles and documents

The discovery of 4-{l-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]- 3thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin e2 subtype 4 receptor antagonist

The discovery of highly potent and selective second generation EP4 antagonist MK-2894 (34d) is discussed. This compound exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. It also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.

THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS

The invention is directed to thiophenecarboxamide derivatives of formulae I and II as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoi