Benzoic acid, 4-(1-aminocyclopropyl)-, hydrochloride (1:1)

Base Information

• Chemical Name: Benzoic acid, 4-(1-aminocyclopropyl)-, hydrochloride (1:1)
• CAS No.: 1014645-83-0
• Molecular Formula: C10H12ClNO2
• Molecular Weight: 213.664
• Mol file: 1014645-83-0.mol

Synonyms:Benzoic acid, 4-(1-aminocyclopropyl)-, hydrochloride (1:1)

Chemical Property of Benzoic acid, 4-(1-aminocyclopropyl)-, hydrochloride (1:1)

Chemical Property:

• PSA: 63.32000
• LogP: 2.83490

Purity/Quality:

98%min ^*data from raw suppliers

4-(1-AMINOCYCLOPROPYL)BENZOIC ACID(HYDROCHLORIDE) 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-(1-aminocyclopropyl)-, hydrochloride (1:1)

There total 1 articles about Benzoic acid, 4-(1-aminocyclopropyl)-, hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(1-aminocyclopropyl)benzonitrile (1014645-75-0) → 4-(1-aminocyclopropyl)benzoic acid hydrochloride (1014645-83-0)

Guidance literature:

With hydrogenchloride; water; for 40h; Heating / reflux;

Reference yield: 95.6%

methanol (67-56-1) + 4-(1-aminocyclopropyl)benzoic acid hydrochloride (1014645-83-0) → methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (1014645-87-4)

Guidance literature:

With thionyl chloride; Reflux;

Reference yield:

4-(1-aminocyclopropyl)benzoic acid hydrochloride (1014645-83-0) + 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-5-carboxylic acid (1417743-24-8) → tert-butyl 5-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)-6-azaspiro[2.5]octane-6-carboxylate

Guidance literature:

6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-5-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.5h;

4-(1-aminocyclopropyl)benzoic acid hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

upstream raw materials:

4-(1-aminocyclopropyl)benzonitrile

Downstream raw materials:

methyl 4-(1-aminocyclopropyl)benzoate hydrochloride

4-(1-aminocyclopropyl)-benzoic acid methyl ester