1014698-47-5

Upstream product

• 1030595-58-4 C₁₀H₁₄F₂O₅ 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 1014698-48-6 ethyl 2-(6-O-(tert-butyldiphenylsilyl)-β-D-allopyranosyl)-2,2-difluoroacetate 
• 1149347-37-4 C₂₆H₃₂F₂O₆Si 

Relevant academic research and scientific papers

Approaches to the synthesis of CF2-analogues of 2-deoxy-2-aminoglycosides

The preparation of a fluorinated C-glycosidic analogue of a 2-deoxy-2-acetamido-d-altrose is described. The synthetic sequence involves the addition of a difluoroenoxysilane to a d-glucal, an epoxidation of the resulting unsaturated CF2-glycoside and a ring-opening reaction with TMSN3. An Overman rearrangement of the unsaturated intermediate is also described.

Synthesis of α-CF2-mannosides and their conversion to fluorinated pseudoglycopeptides

(Chemical Equation Presented) A methodology allowing the synthesis α-CF2-mannosides, based on the addition of a difluoroenoxysilane to a glycal followed by a dihydroxylation reaction, is described. The resulting 2,2-difluoro-2-mannosylacetate is converted into two pseudoglycopeptides which may act as E- and P-selectin inhibitors.