1015-64-1

Usage

Uses

Used in Pharmaceutical Industry:
Phendione is utilized as a key building block for the synthesis of various pharmaceuticals and biologically active compounds due to its unique structure and properties. Its ability to form stable complexes with metal ions makes it a promising candidate for the development of new drugs with enhanced therapeutic effects.
Used in Coordination Chemistry:
In the field of coordination chemistry, phendione serves as a versatile ligand, forming stable complexes with metal ions. This property allows for the exploration of its potential applications in catalysis, sensing, and materials science.
Used in Antimicrobial Applications:
Phendione is employed as an antimicrobial agent, exhibiting activity against a range of bacteria. Its ability to inhibit bacterial growth makes it a valuable component in the development of new antimicrobial drugs and treatments.
Used in Antifungal Applications:
As an antifungal agent, phendione demonstrates potential in combating fungal infections. Its effectiveness against various fungi positions it as a candidate for further research and development in antifungal drug discovery.
Used in Antiparasitic Applications:
Phendione also shows promise as an antiparasitic agent, with potential applications in treating parasitic infections. Its ability to target and inhibit the growth of parasites makes it a valuable chemical for the development of new antiparasitic treatments.

Upstream product

• 108-75-8 2,4,6-trimethyl-pyridine 
• 100615-98-3 (3-anilino-crotonoyl)-carbamic acid ethyl ester 
• 29638-50-4 6-methyl-2-phenyl-amino-4H-1,3-oxazin-4-one 
• 62-53-3 aniline 
• 2911-21-9 2,4-dioxo-6-methyl-3,4-dihydro-2H-1,3-oxazine 
• 91114-97-5 5-acetyl-4-hydroxy-3,6-dihydro-2H-1,3-thiazine-2,6-dione 
• 7190-58-1 Ethyl N-(acetoacetyl)carbamate 
• 622-34-4 1-phenylcyanamide 

Downstream Products

• 1548336-49-7 4-amino-6-((3-chloro-5-oxo-6-phenyl-5,6-dihydroimidazo[1,2-c]pyrimidin-7-yl)methoxy)pyrimidine-5-carbonitrile 
• 1548342-32-0 3-chloro-7-(hydroxymethyl)-6-phenylimidazo[1,2-c]pyrimidin-5(6H)-one 
• 1548342-36-4 4-chloro-6-((3-chloro-5-oxo-6-phenyl-5,6-dihydroimidazo[1,2-c]pyrimidin-7-yl)methoxy)pyrimidine-5-carbonitrile 
• 1548342-40-0 4-((3-chloro-5-oxo-6-phenyl-5,6-dihydroimidazo[1,2-c]pyrimidin-7-yl)methoxy)-6-(4-methoxybenzylamino)pyrimidine-5-carbonitrile 
• 1548336-56-6 7-((9H-purin-6-yloxy)methyl)-3-chloro-6-phenylimidazo[1,2-c]pyrimidin-5(6H)-one 
• 1548342-43-3 3-chloro-6-phenyl-7-((9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yloxy)methyl)imidazo[1,2-c]pyrimidin-5(6H)-one 
• 1548336-01-1 7-(1-(9H-purin-6-ylamino)ethyl)-3-chloro-6-phenylimidazo[1,2-c]pyrimidin-5(6H)-one 
• 1548341-92-9 7-(1-aminoethyl)-3-chloro-6-phenylimidazo[1,2-c]pyrimidin-5(6H)-one 
• 1548341-84-9 7-(1-azidoethyl)-3-chloro-6-phenylimidazo[1,2-c]pyrimidin-5(6H)-one 
• 1548341-78-1 3-chloro-7-(1-hydroxyethyl)-6-phenylimidazo[1,2-c]pyrimidin-5(6H)-one 
• 1548341-72-5 3-chloro-5-oxo-6-phenyl-5,6-dihydroimidazo[1,2-c]pyrimidine-7-carbaldehyde 
• 1548341-67-8 3-chloro-7-methyl-6-phenylimidazo[1,2-c]pyrimidin-5(6H)-one 
• 1548341-63-4 7-methyl-6-phenylimidazo[1,2-c]pyrimidin-5(6H)-one 
• 39807-07-3 4-butylamino-6-methyl-1-phenyl-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

A new synthesis of 1,3-thiazines and their transformation into 1-substituted-6-alkyluracils by extrusion of carbonyl sulfide

A simple synthesis of 5-acyl-4-hydroxy-3,6-dihydro-2H-1,3-thiazine-2,6-diones from malonic acid, potassium thiocyanate and acid anhydrides is described. A new, general, regioselective method for the synthesis of 1-substituted-6-alkyluracils by the reaction of these thiazines with primary alkyl and arylamines is reported.

Azines and azoles: CXXII. New regioselective synthesis of 1-substituted 6-alkyluracils

Readily available 5-acyl-4-hydroxy-3,6-dihydro-2H-1,3-thiazine-2,6-diones with primary alkyl- and arylamines in mild conditions (boiling in propan-2-ol) to give Schiff bases. In more rigid conditions (boiling in DMF), the reaction is accompanied by COS liberation and provides 1-substituted 6-alkyluracils. This previously unknown reaction possesses a considerable synthetic potential and can be considered as a new, general, and regioselective synthetic approach to 1-substituted 6-alkyluracils.

NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS

The invention relates to novel heteroaryl and heterocycle compounds of formula I and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune diseases and cancer.

NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS

The invention relates to novel heteroaryl and heterocycle compounds and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3k and for treating inflammatory and autoimmune disorders diseases and cancer.

NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITION AND METHODS THEREOF

Disclosed are novel heteroaryl and heterocycle compounds of formula I-1, I-2 or I-3 and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune diseases and cancer.

NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS

Provided are novel heteroaryl and heterocycle compounds of formula (I-1), (I-2) or (I-3) and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune disorders diseases and cancer.

Heterocyclic Transformations. Part 5: Studies in Reactions of 6-Methyl-1,3-oxazine-2,4(3H)-dione with Arylamines - a Facile Synthesis of 1-Aryl-6-methyluracils

6-Methyl-1,3-oxazine-2,4(3H)-dione 1 reacts with 2 equiv. arylamines 3 at 150-160 deg C to give 1-aryl-6-methyluracils 5 or 1-aryl-3-(3-aryliminobutanoyl)ureas 4.The latter - as well as mixtures of 1 and 3 (2 equiv.) on refluxing, in isopentanol in some cases or in acetic acid in general - provide a facile synthesis of 5.The role of the stoichiometric excess of arylamines as against an equiv. of an alkylamine in similar reactions has been rationalized.