10152-62-2Relevant articles and documents
The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors
Tanaka, Akito,Nishizaki, Tomoyuki
, p. 1037 - 1040 (2003)
The newly synthesized linoleic acid derivative, FR236924, induces a long-lasting facilitation of hippocampal neurotransmission based on a persistent enhancement in the activity of presynaptic nicotinic ACh receptors via a PKC pathway and the ensuing increase in glutamate release, not only in vitro but in vivo at a low dosage (2 mg/kg, ip), which suggested the possibility of its use as a promising anti-dementia drug.
New family of cyclopropanating reagents: Synthesis, reactivity, and stability studies of iodomethylzinc phenoxides
Charette, Andre B.,Francoeur, Sebastien,Martel, Jonathan,Wilb, Nicole
, p. 4539 - 4542 (2000)
A valuable alternative to the traditional Simmons-Smith reagents is offered by the title compounds, as a result of their ease of preparation and high reactivities towards unfunctionalized olefins (see scheme).
Synthesis of dihydrosterculic acid-based monoglucosyl diacylglycerol and its analogues and their biological evaluation
Srikanth, Vudhgiri,Prasad,Poornachandra,Phani Babu,Ganesh Kumar,Jagadeesh,Jala, Ram Chandra Reddy
, p. 134 - 145 (2016)
In the present study, Lactobacillus plantarum glycolipid (GL1) molecule in β-configuration and its fatty acid analogues were synthesized using trichloroacetimidate methodology. The β-configuration of the GL1 molecule was unambiguously assigned by NMR studies using 2D-ROESY (NOE) and J-coupling analysis. Dihydrosterculic acid was synthesized using Furukawa's reagent and the selective esterification of dihydrosterculic acid at C-3 position of glycerol was achieved with EDC-HCl at 0 °C. In vitro cytotoxicity of the GL1 molecule and its fatty acid analogues was evaluated against DU145, A549, SKOV3 and MCF7 cell lines. Among all the synthesized molecules, the GL1 molecule and compound 7d showed moderate activity, while the compound 7b showed promising activity against all the tested cell lines with IC50 values of 20.1, 18.2, 19.1 and 17.6 ?1/4M, respectively. In addition, all tested compounds showed poor cytotoxicity against normal HUVEC cells. The MCF7 cells when treated with compound 7b showed lower bromodeoxyuridine incorporation levels as compared to untreated cells, suggesting that the compound 7b was highly effective and inhibited the cell proliferation. In addition, the compounds showed significant increase in caspases 3 and 9 levels by inducing apoptosis in MCF 7 cells.
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Hofmann et al.
, p. 1799,1802 (1954)
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Synergistic effect of additives on cyclopropanation of olefins
Cheng, Donghao,Huang, Deshun,Shi, Yian
, p. 5588 - 5591 (2013)
An efficient cyclopropanation of olefins with Zn(CH2I) 2, a catalytic amount of CCl3CO2H, and 1,2-dimethoxyethane at room temperature is described. A wide variety of olefins, including acid-sensitive substrates,
