101523-04-0

Basic information

• Product Name: Methylphosphonic acid monobenzyl ester
• Synonyms: Methylphosphonic acid monobenzyl ester
• CAS NO: 101523-04-0
• Molecular Weight: 186.147
• Mol File: 101523-04-0.mol

Chemical Properties

• CAS DataBase Reference: Methylphosphonic acid monobenzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methylphosphonic acid monobenzyl ester(101523-04-0)
• EPA Substance Registry System: Methylphosphonic acid monobenzyl ester(101523-04-0)

Safety Data

• Hazardous Substances Data: 101523-04-0(Hazardous Substances Data)

Upstream product

• 676-97-1 methylphosphonic acid dichloroanhydride 
• 100-51-6 benzyl alcohol 
• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 19236-58-9 dibenzyl methylphosphonate 
• 538-60-3 dibenzyl hydrogen phosphite 

Downstream Products

• 86530-02-1 (3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester 
• 86509-39-9 (3-{(2S,3R)-3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester 
• 86509-50-4 [(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-methoxy-7-oxo-1-aza-bicyclo[3.2.0]hept-2-en-2-yl]-phosphonic acid benzyl ester methyl ester 
• 86509-48-0 [(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3,7-dioxo-1-aza-bicyclo[3.2.0]hept-2-yl]-phosphonic acid benzyl ester methyl ester 
• 86509-41-3 {3-[(2S,3R)-3-((S)-1-Hydroxy-ethyl)-4-oxo-azetidin-2-yl]-2-oxo-propyl}-phosphonic acid benzyl ester methyl ester 
• 122086-11-7 benzyl methylphosphonochloridate 
• 710-09-8 methyl-phosphonic acid benzyl methyl ester 
• 900151-14-6 2,3,5-tri-O-benzyl-α-D-ribofuranosyl benzyl methylphosphonate 

Relevant articles and documents

Solid-Phase Synthesis of the Aged-Nonapeptide-Nerve-Agent Adduct of Butyrylcholinesterase as Reference Materials for Analytical Verification

Two pathways were developed and investigated for the synthesis of the ‘aged’-nonapeptide nerve-agent bioadduct of human butyrylcholinesterase (BuChE). Considering the fast ageing of nerve-agent adducts of BuChE in patients and biomedical samples this target molecule is of paramount relevance for quantitative analysis with respect to the Chemical Weapons Convention. Two approaches using a precursor bearing a hydroxyl on its phosphonyl moiety and a benzyl protected precursor were considered. Several impurities were identified and circumvented during the optimization of the peptide synthesis step. The ‘aged’-nonapeptide adduct was successfully synthesized by solid-phase-peptide-synthesis (SPPS).

A concise synthesis of α-D-ribofuranosyl alkylphosphonates - Putative substrate intermediates for the carbon-phosphorous lyase system

Carbon-phosphorous lyase is a multienzyme system found in many species of bacteria that is distinguished by its ability to hydrolyze a broad array of unactivated alkylphosphonates. α-D-Ribofuranosyl alkylphosphonates are potential metabolic intermediates

α-haloenamines as reagents for the conversion of phosphorus oxyacids to their halogenated analogues

Phosphorus oxyacids are converted to their halogenated analogues under mild conditions. α-Haloenamines are shown to be effective halogen transfer reagents affording good to high yields of the desired products at reaction times, in some cases, less than one minute. Georg Thieme Verlag Stuttgart.

Phosphorous-containing cysteine and serine protease inhibitors

The present invention is directed to novel phosphorous-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.

SYNTHESIS OF CARBAPENEM-3-PHOSPHONIC ACID DERIVATIVES

The synthesis of 6-(1-hydroxyethyl)-2-oxocarbapenem-3-phosphonic acid derivatives, starting from 3-iodomethyl-2-oxoazetidine is described.