122086-11-7Relevant academic research and scientific papers
Evaluation of phosphorus-containing inhibitors of γ-glutamyl hydrolase
Rodriguez, Chester E.,Holmes, H. Michael,Mlodnosky, Karyn L.,Lam, Vinh Q.,Berkman, Clifford E.
, p. 1521 - 1524 (1998)
Several putative, phosphorus-containing inhibitors of γ-glutamyl hydrolase were synthesized and evaluated for inhibitory activity. The phosphonamidoic acids were shown to be weak competitive inhibitors while both a phosphoramidate diester and a phosphonamidate ester were shown to be potent time-dependent inactivators, presumably through irreversible phosphorylation of an active site nucleophile.
PHOSPHONATES SYNTHONS FOR THE SYNTHESIS OF PHOSPHONATES DERIVATIVES SHOWING BETTER BIOAVAILABILITY
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Page/Page column 13; 16-17, (2010/12/31)
Synthons for the synthesis of phosphonates prodrugs POM and POC, especially for direct Cross Metathesis.
α-haloenamines as reagents for the conversion of phosphorus oxyacids to their halogenated analogues
Norlin, Rikard,Juhlin, Lars,Lind, Per,Trogen, Lars
, p. 1765 - 1770 (2007/10/03)
Phosphorus oxyacids are converted to their halogenated analogues under mild conditions. α-Haloenamines are shown to be effective halogen transfer reagents affording good to high yields of the desired products at reaction times, in some cases, less than one minute. Georg Thieme Verlag Stuttgart.
A convenient two-step one-pot synthesis of phosphonamidates
Mlodnosky, Karyn L.,Holmes, H. Michael,Lam, Vinh Q.,Berkman, Clifford E.
, p. 8803 - 8806 (2007/10/03)
Phosphonamidates are formed in high yield from a one-pot sequential reaction of a phosphonyl dichloride with an alcohol and then an amine in the presence of catalytic 1H-tetrazole. Undesired disubstitution of the phoshphonyl dichloride by the alcohol or the amine is minimal due to the presence of tetrazole.
Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase
Wu, Ronghui,Saab, Nada H.,Huang, Huatao,Wiest, Laurie,Pegg, Anthony E.,Casero Jr., Robert A.,Woster, Patrick M.
, p. 825 - 836 (2007/10/03)
Polyamine analogues such as bis(ethyl)norspermine and N1-ethyl-N11-[(cyclopropyl)methyl]-4,8-diazaundecane (CPENSpm) act as inhibitors of the enzyme spermidine/spermine-N1-acetyltransferase (SSAT) in vitro and possess impr
Convenient "one-pot" synthesis of chlorophosphonates, chlorophosphates and chlorophosphoramides from the corresponding benzyl esters
Saady, Mourad
, p. 4785 - 4786 (2007/10/02)
Selective monodeprotection of alkyl phosphonate, phosphate and phosphoramide benzyl esters using quinuclidine and chlorination of the subsequent salts allows preparation of various alkyl phosphonochloridates, monochlorophosphates and monochlorophosphoramides in a convenient "one-pot" procedure.
