10154-80-0Relevant articles and documents
Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions
Blakemore, David C.,Cook, Xinlan A. F.,Moses, Ian B.,Pantaine, Lo?c R. E.,Sach, Neal W.,Shavnya, Andre,Willis, Michael C.
supporting information, p. 22461 - 22468 (2021/09/09)
Heteroaromatic sulfinates are effective nucleophilic reagents in Pd0-catalyzed cross-coupling reactions with aryl halides. However, metal sulfinate salts can be challenging to purify, solubilize in reaction media, and are not tolerant to multi-step transformations. Here we introduce base-activated, latent sulfinate reagents: β-nitrile and β-ester sulfones. We show that under the cross-coupling conditions, these species generate the sulfinate salt in situ, which then undergo efficient palladium-catalyzed desulfinative cross-coupling with (hetero)aryl bromides to deliver a broad range of biaryls. These latent sulfinate reagents have proven to be stable through multi-step substrate elaboration, and amenable to scale-up.
Method for synthesizing 3-sulfonyl nitrile compound
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Paragraph 0010, (2017/04/03)
The invention discloses a method for synthesizing a 3-sulfonyl nitrile compound. The method includes the steps of using substituted sulfonhydrazide and an acrylonitrile compound as raw materials for a reaction in water by heating to obtain the 3-sulfonyl nitrile compound, and after the reaction, obtaining the 3-sulfonyl nitrile compound with a purity of 95% or above by simple separation. Compared with other synthetic methods, the method is simpler in reaction step, more environmentally friendly in synthesis and higher in yield. Important nitrile pharmaceutical chemical intermediates are directly synthesized by one step, and a novel method is provided for synthesizing the sulfonyl-substituted nitrile compound for the field of chemical synthesis.
