1015445-59-6

Basic information

• Product Name: {4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-pyridyl}(tetrahydro-2H-pyran-4-yl)amine
• Synonyms: {4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-pyridyl}(tetrahydro-2H-pyran-4-yl)amine
• CAS NO: 1015445-59-6
• Molecular Weight: 384.477
• Mol File: 1015445-59-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: {4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-pyridyl}(tetrahydro-2H-pyran-4-yl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: {4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-pyridyl}(tetrahydro-2H-pyran-4-yl)amine(1015445-59-6)
• EPA Substance Registry System: {4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-pyridyl}(tetrahydro-2H-pyran-4-yl)amine(1015445-59-6)

Safety Data

• Hazardous Substances Data: 1015445-59-6(Hazardous Substances Data)

Upstream product

• 581098-38-6 4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione 
• 38041-19-9 4-aminotetrahydropyran 
• 549505-59-1 2-fluoro-4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridine 

Downstream Products

• 1289617-83-9 4-(4-(4-fluorophenyl)-2-(methylsulfinyl)-1H-imidazol-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine 
• 1289617-66-8 4-(4-(4-fluorophenyl)-2-(methylsulfinyl)-1H-imidazol-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine 
• 1289617-08-8 4-(4-(4-fluorophenyl)-2-(methylsulfinyl)-1H-imidazol-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine 

Relevant articles and documents

Chiral sulfoxides as metabolites of 2-thioimidazole-based p38α mitogen-activated protein kinase inhibitors: Enantioselective synthesis and biological evaluation

Figure Presented. A number of pharmaceutically important drugs contain asymmetric sulfinyl moieties, so the biological evaluation of chiral sulfoxides as human drug metabolites is important for the development of safe and effective pharmaceuticals. Asymme

Design, synthesis, and biological evaluation of novel tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: Focus on optimized interactions with the enzyme's surface-exposed front region

The synthesis, biological testing, and SAR of novel 2,4,5- and 1,2,4,5-substituted 2-thioimidazoles are described. Amino, oxy, or thioxy substituents at the 2-position of the pyridinyl moiety were evaluated for their contributions to inhibitor potency and