101554-19-2

Upstream product

• 14206-38-3 Neu5AcαOBn 
• 83107-51-1 Methyl-(5-acetamido-4,7,8,9-tetra-O-acetyl-2,3,5-tridesoxy-D-glycero-β-D-galacto-2-nonulopyranosylbromid)onat 
• 6931-68-6 methyl 5-acetamido-2,4,7,8,9-penta-O-acetyl-3,5-dideoxy-D-glycero-D-galacto-2-nonulopyranosonate 
• 108740-39-2 (1S,2R)-1-((2R,3R,4S,6R)-3-acetamido-4,6-diacetoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate 
• 19342-75-7 methyl (benzyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosid)onate 

Downstream Products

• 15964-52-0 N-butanoyl-D-neuraminic acid benzyl glycoside 
• 765302-21-4 N-phenylacetyl-D-neuraminic acid benzyl glycoside 
• 765302-19-0 N-iso-butanoyl-D-neuraminic acid benzyl glycoside 
• 174312-83-5 (2R,4S,5R,6R)-4-Acetoxy-6-((1R,2R)-1-acetoxy-3-benzoyloxy-2-hydroxy-propyl)-2-benzyloxy-5-(2-benzyloxy-acetylamino)-tetrahydro-pyran-2-carboxylic acid benzyl ester 
• 174312-81-3 (2R,4S,5R,6R)-4-Acetoxy-6-[(S)-acetoxy-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-2-benzyloxy-5-(2-benzyloxy-acetylamino)-tetrahydro-pyran-2-carboxylic acid benzyl ester 
• 174312-82-4 (2R,4S,5R,6R)-4-Acetoxy-6-((1R,2R)-1-acetoxy-2,3-dihydroxy-propyl)-2-benzyloxy-5-(2-benzyloxy-acetylamino)-tetrahydro-pyran-2-carboxylic acid benzyl ester 
• 174312-80-2 (2R,4S,5R,6R)-2-Benzyloxy-5-(2-benzyloxy-acetylamino)-6-[(S)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-4-hydroxy-tetrahydro-pyran-2-carboxylic acid benzyl ester 
• 174312-79-9 (2R,4S,5R,6R)-2-Benzyloxy-5-(2-benzyloxy-acetylamino)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid benzyl ester 
• 15964-53-1 N-benzoyl-D-neuraminic acid benzyl glycoside 
• 15964-51-9 N-propionyl-D-neuraminic acid benzyl glycoside 
• 352437-52-6 benzyl 5-azido-3,4-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid 
• 1054635-30-1 (2R,4S,5R,6R)-5-(2-Acetoxy-acetylamino)-2-benzyloxy-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid 
• 352437-57-1 methyl (benzyl 4-O-acetyl-5-azido-3,5-dideoxy-9-O-(4-methoxybenzyl)-D-glycero-α-D-galacto-non-2-ulopyranosid)onate 
• 352437-49-1 methyl (benzyl 5-azido-4,7,8,9-tetra-O-acetyl-3,5-di-deoxy-D-glycero-α-D-galacto-non-2-ulopyranoside)onate 

Relevant academic research and scientific papers

Accessibility of N-acyl-D-mannosamines to N-acetyl-D-neuraminic acid aldolase

N-Acetyl-D-neuraminic acid (NeuNAc) aldolase is an important enzyme for the metabolic engineering of cell-surface NeuNAc using chemically modified D-mannosamines. To explore the optimal substrates for this application, eight N-acyl derivatives of D-mannos

5-azido derivatives of neuraminic acid - Synthesis and structure

Benzyl sialoside 1 was transformed into the corresponding 5-azido derivative 4 by N-nitrosation of the 5-acetylamino group and treatment with base followed by hydrazoic acid or, alternatively, by N,O-deacetylation followed by diazo group transfer to the amino moiety by means of TfN3. Regioselective 4-O-acetylation and introduction of the MPM group at 9-O afforded glycosyl acceptor 11. N,O-Deacetylation of ethyl 2-thiosialoside 13 afforded 14 which, after diazo group transfer to the amino group, furnished 5-azido derivative 16, which can serve as a sialyl donor. Activation of the ethylthio leaving group in the absence of an acceptor afforded 2,3-dehydro derivative 17. Regioselective 4-O-acetylation and 9-O-benzylation furnished glycosyl acceptor 22. An X-ray analysis was obtained from crystals of the 7,8,9-O-unprotected intermediate 21.

Synthesis of N-glycolyl-8-o-sulfoneuraminic acid

N-Glycolyl-8-O-sulfoneuraminic acid (1) was synthesized for the first time in good yield. The key intermediates for synthesis of 1, neoraminic acid O- benzyl α-glycoside (3) and neuraminic acid S-methyl α-glucoside (10) were prepared from readily availabl

Synthesis of fluorescent 4-methyl-7-thiocoumaryl S-glycosides of sialic acid

Condensation of 4-methyl-7-thiocoumarin sodium salt with methyl 5-N- acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2,3,5-trideoxy-D-glycero-D-galacto-2- nonulopyranosonate (2), methyl 5-N-(O-acetylglycolyl)-4,7,8,9-tetra-O- acetyl-2-chloro-2,3,6-trideoxy-D-glyce

A simple procedure for the synthesis of the methyl and benzyl glycosides of Neu5Ac and 4-epi-Neu5Ac. Conversion of the benzyl and methyl glycosides of Neu5Ac into N-trifluoroacetylneuraminic acid benzyl glycosides

From the reaction products of the Kuhn-Bashang synthesis of Neu5Ac, 5-acetamido-3,5-dideoxy-α- and -β-D-glycero-D-talo-2-nonulopyranosonic acid (4-epi-Neu5Ac) were isolated as the acetylated methyl esters (1 and 2).Treatment of methyl (5-acetamido-4,7,8,9