1015870-41-3Relevant articles and documents
Synthesis, characterization and catalytic evaluation of BiCl 3-ZrO2 for the synthesis of novel pyrazolyl chalcones
Tarannum, Saima,Siddiqui, Zeba N.
, p. 262 - 273 (2014)
BiCl3-ZrO2 as an efficient heterogeneous catalyst is prepared by a simple process and characterized by FT-IR, powder XRD, SEM-EDX, XRF and BET surface area analyses. Thermal stability of the catalyst has been examined by DSC-TG analyses. The catalyst is recyclable for several runs preserving its high activity. The catalytic activity of BiCl3- ZrO2 is explained by synthesizing a series of novel pyrazolyl chalcones in excellent yields.
Green method for the synthesis of chromeno[2,3- C ]pyrazol-4(1 H)-ones through ionic liquid promoted directed annulation of 5-(aryloxy)-1 H -pyrazole-4-carbaldehydes in aqueous media
Li, He,Liu, Chenjiang,Zhang, Yonghong,Sun, Yadong,Wang, Bin,Liu, Wenbo
, p. 932 - 935 (2015/03/30)
The first classical heterocyclic ionic liquid (IL) promoted C-H bond oxidant cross-coupling reaction for the intramolecular annulation of 5-(aryloxy)-1H-pyrazole-4-carbaldehydes to chromeno[2,3-c]pyrazol-4(1H)-ones has been disclosed. The promoter 1,3-dibutyl-1H-benzo[d][1,2,3]triazol-3-ium bromide can be easily recycled and reused with the same efficacies for at least five cycles in aqueous medium. The strategy works smoothly and provides an applicable protocol to construct a wide range of products.
Design, synthesis, and antibacterial evaluation of new Schiff's base derivatives bearing nitroimidazole and pyrazole nuclei as potent E. coli FabH inhibitors
Sangani, Chetan B.,Makwana, Jigar A.,Duan, Yong-Tao,Tarpada, Umesh P.,Patel, Yogesh S.,Patel, Ketan B.,Dave, Vivek N.,Zhu, Hai-Liang
, p. 10137 - 10149 (2016/01/12)
New Schiff's base derivatives 5a-j have been synthesized by reaction between 5-aryloxypyrazole-4-carbaldehydes 3a-j and 2-(2-methyl-5-nitro-1Himidazol- 1-yl)acetohydrazide 4 in the presence of nickel (II) nitrate as a catalyst in ethanol at room temperatu
Synthesis and evaluation on anticonvulsant activities of pyrazolyl semicarbazones
Deng, Xian-Qing,Song, Ming-Xia,Yu, Hai-Hong
, p. 8234 - 8238 (2015/02/02)
In this paper, a series of 2-[(5-phenoxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-methylene]hydrazine carboxamides were synthesized and evaluated for their anticonvulsant activities using the maximal electroshock method. Their neurotoxicities were determined ap
Design and synthesis of pyrazolyl thiosemicarbazones as new anticonvulsants
Deng, Xian Qing,Song, Ming Xia
, p. 2733 - 2737 (2015/04/22)
A series of pyrazolyl thiosemicarbazone derivatives were synthesized and evaluated for their anticonvulsant activity using the maximal electroshock (MES) method. Interestingly, all compounds prepared showed long duration of protection effect in the MES sc
Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA and QRSA)
Song, Ming-Xia,Zheng, Chang-Ji,Deng, Xian-Qing,Sun, Liang-Peng,Wu, Yan,Hong, Lan,Li, Ying-Jing,Liu, Yi,Wei, Zhi-Yu,Jin, Ming-Jun,Piao, Hu-Ri
, p. 376 - 385 (2013/03/28)
With an intention to synergize the anti-bacterial activity of 5-aryloxy pyrazole and rhodanine derivatives, eight series of hybrid compounds have been synthesized and evaluated for their antibacterial activity. The majority of the synthesized compounds showed good inhibitory activity against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA, QRSA) with minimum inhibitory concentration (MIC) values in the range of 1-32 μg/mL. The cytotoxicity test suggests that these compounds exhibited in vitro antibacterial activity at non-cytotoxic concentrations. These studies therefore suggest that rhodanine-based 5-aryloxy pyrazoles are interesting scaffolds for the development of novel Gram-positive antibacterial agents.
One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation
Jardosh, Hardik H.,Sangani, Chetan B.,Patel, Manish P.,Patel, Ranjan G.
, p. 123 - 126 (2013/06/26)
A new series of pyrido[1,2-a]benzimidazole derivatives bearing the aryloxypyrazole nucleus have been synthesized by base-catalyzed cyclocondensation reaction through multi-component reaction (MCR) approach. All the synthesized compounds were investigated
Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents
Zheng, Chang-Ji,Song, Ming-Xia,Sun, Liang-Peng,Wu, Yan,Hong, Lan,Piao, Hu-Ri
, p. 7024 - 7028 (2013/01/15)
Three novel series of 5-aryloxypyrazole derivatives have been synthesized and tested for their antibacterial activity. The majority of the synthesized compounds showed potent inhibitory activity against Gram-positive bacteria Staphylococcus aureus 4220, especially against the strains of multidrug-resistant clinical isolates (MRSA3167/3506 and QRSA3505/3519). Among which compounds IIIb, IIIg and IIIm showed the most potent levels of activity (MIC = 1 μg/mL) against the multidrug-resistant strains. And cytotoxic activity assay showed that the compounds tested did not affect cell viability on the Human cervical (HeLa) cells at their MICs. The current study therefore suggests that 5-aryloxypyrazoles bearing a rhodanine-3-aromatic acid moiety are promising scaffolds for the development of novel Gram-positive antibacterial agents.
Synthesis and in vitro antimicrobial screening of new pyrano[4,3-b]pyrane derivatives of 1H-pyrazole
Sangani, Chetan B.,Mungra, Divyesh C.,Patel, Manish P.,Patel, Ranjan G.
, p. 57 - 60 (2012/04/04)
A new series of pyrano[4,3-b]pyrane 4a-l bearing 1H-pyrazole has been synthesized by one pot base catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde 1a-l, malononitrile 2 and 4-hydroxy-6-methylpyrone 3. All the synthesized compounds were screened against six bacterial pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli and antifungal activity against, two fungal pathogens, A. fumigatus and C. albicans using broth microdilution MIC method. Some of the compounds are found to be equipotent or more potent than that of commercial drugs, against most of employed strains.
Microwave-assisted synthesis of novel 4H-chromene derivatives bearing phenoxypyrazole and their antimicrobial activity assessment
Sangani, Chetan B.,Shah, Nimesh M.,Patel, Manish P.,Patel, Ranjan G.
, p. 1165 - 1174 (2012/11/13)
A new series of 4H-chromene derivatives 4a-p bearing the 5-phenoxypyrazole nucleus were synthesized under microwave irradiation by the reaction of 5-phenoxypyrazole-4-carbaldehydes 1a-h, malononitrile 2 and compounds 1,3-cyclohexanedione and dimedone (3a
