1016169-41-7

Upstream product

• 101671-00-5 (E)-2-(4-methylphenyl)-1-nitroethene 
• 103185-60-0 N-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-N'-(4-methoxy-phenyl)-hydrazine 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 104-88-1 4-chlorobenzaldehyde 
• 104-87-0 4-methyl-benzaldehyde 

Relevant academic research and scientific papers

Regioselective, One-Pot, Three-Component Synthesis of 1,3,4- and 1,3,5-Triarylpyrazoles from 1- and 2-Aryl-1-alkenyl Sulfones

A one-pot, three-component coupling of aldehydes with hydrazines and 1-aryl-1-alkenyl sulfones or 2-aryl-1-alkenyl sulfones for the regioselective synthesis of 1,3,4- and 1,3,5-triarylpyrazoles was developed. In our developed procedure, 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) worked as an effective oxidant, and the addition of an strong acid was not necessary. We synthesized 1,3,4- and 1,3,5-triarylpyrazoles containing acid-labile functionalities in a one-pot reaction in good yields.

Base-mediated reaction of hydrazones and nitroolefins with a reversed regioselectivity: A novel synthesis of 1,3,4-Trisubstituted pyrazoles

A regioselective synthesis of 1,3,4-tri- or 1,3,4,5-tetrasubstituted pyrazoles by the reaction of hydrazones with nitroolefins is described. Mediated with strong bases such as t-Bu OK, the reaction exhibits a reversed, exclusive 1,3,4-regioselectivity. Su