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10162-99-9 Usage


(2beta,3beta,5beta,14xi)-2,3,14-trihydroxypregn-7-ene-6,20-dione, also known as 2,3,14-trihydroxy-6,20-dioxopregn-7-ene, is a steroid hormone and a derivative of the hormone progesterone. It is a naturally occurring steroid in the body and plays a crucial role in the regulation of the menstrual cycle and pregnancy. Its chemical structure consists of a pregnane backbone with hydroxyl groups at the 2, 3, and 14 positions, and ketones at the 6 and 20 positions.


Used in Gynecological and Reproductive Medicine:
(2beta,3beta,5beta,14xi)-2,3,14-trihydroxypregn-7-ene-6,20-dione is used as a medication for the treatment of various gynecological and reproductive disorders, such as menstrual irregularities, infertility, and hormone replacement therapy. It helps regulate hormonal balance and supports the normal functioning of the reproductive system.
Used in Research:
(2beta,3beta,5beta,14xi)-2,3,14-trihydroxypregn-7-ene-6,20-dione is used as a precursor in the synthesis of other steroid hormones. It serves as an important compound in the development of new medications and therapies for various conditions related to hormonal imbalances and reproductive health.
Used in Pharmaceutical Industry:
(2beta,3beta,5beta,14xi)-2,3,14-trihydroxypregn-7-ene-6,20-dione is used as an active pharmaceutical ingredient in the formulation of drugs for the treatment of gynecological and reproductive disorders. It is incorporated into medications to provide therapeutic benefits to patients suffering from hormonal imbalances and related conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 10162-99-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,6 and 2 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 10162-99:
69 % 10 = 9
So 10162-99-9 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017


1.1 GHS Product identifier

Product name poststerone

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10162-99-9 SDS

10162-99-9Relevant articles and documents

Backstabbing P-gp: Side-chain cleaved ecdysteroid 2,3-dioxolanes hyper-sensitize MDR cancer cells to doxorubicin without efflux inhibition

Hunyadi, Attila,Csábi, József,Martins, Ana,Molnár, Joseph,Balázs, Attila,Tóth, Gábor

, (2017)

P-glycoprotein (P-gp, ABCB1) over-expression, causing a multi-drug resistant (MDR) phenotype, is a major problem in cancer chemotherapy that urgently requires novel approaches. Our previous studies showed certain ecdysteroid derivatives as promising chemo-sensitizers against MDR and non-MDR cancer cell lines while also exerting mild to moderate inhibition of P-gp function. Here we report the preparation of a set of substituted 2,3-dioxolane derivatives of poststerone, a known in vivo metabolite of 20-hydroxyecdysone (20E). In contrast with previously studied ecdysteroid dioxolanes, the majority of the new compounds did not inhibit the efflux function of P-gp. Nevertheless, a strong, dose dependent sensitization to doxorubicin was observed on a P-gp transfected cancer cell line and on its susceptible counterpart. We also observed that the MDR cell line was more sensitive to the compounds' effect than the non-MDR. Our results showed for the first time that the chemo-sensitizing activity of ecdysteroids can be fully independent of functional efflux pump inhibition, and suggest these compounds as favorable leads against MDR cancer.

Rapid, laser-induced conversion of 20-hydroxyecdysone-A follow-up study on the products obtained

Lai, Wan-Chun,Dankó, Balázs,Csábi, József,Kele, Zoltán,Chang, Fang-Rong,Pascu, Mihail L.,Gáti, Tamás,Simon, András,Amaral, Leonard,Tóth, Gábor,Hunyadi, Attila

, p. 56 - 62 (2014)

We have recently reported the set-up of an experimental system for the laser-induced photochemical modification of bioactive substances, where two ecdysteroids, 20-hydroxyecdysone (20E) and its diacetonide derivative served as probes. As a direct continuation of our previous work, three new compounds together with five other ecdysteroid derivatives, have been identified from the novel, laser-induced photo-transformation reaction of 20E. The structures and NMR signal assignment were established by comprehensive one- and two-dimensional NMR spectroscopy supported by mass spectroscopy. Possible ways for the formation of each species is also discussed. Similar to their parental compound, the products obtained are potentially bioactive and worthy for further investigations; due to the low yields, however, a different approach for their higher scale production is suggested.

New cyclic 2,3‐sulfite ester derivatives of poststerone— discriminating diastereomers and probing spatial proximities by NMR and DFT calculations

Balázs, Attila,Hunyadi, Attila,Csábi, József,Tillekeratne, L.M. Viranga,Martins, Ana,Tóth, Gábor

, p. 1102 - 1107 (2018/04/10)


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