1016258-89-1Relevant academic research and scientific papers
SYNTHESIS OF METABOLICALLY STABLE AGENTS FOR ALCOHOL AND DRUG ABUSE
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Page/Page column 48, (2010/04/03)
Disclosed herein are compounds of formula (I); as defined herein, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same, and methods of using these compounds for the treatment of substance addiction.
Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation
Ghirmai, Senait,Azar, Marc R.,Cashman, John R.
experimental part, p. 6671 - 6681 (2010/02/28)
A series of substituted aryl amide derivatives of 6-naltrexamine, 3 designed to be metabolically stable were synthesized and used to characterize the structural requirements for their potency to binding and functional activity of human mu (μ), delta (δ) a
Synthesis and biological evaluation of α- and β-6-amido derivatives of 17-cyclopropylmethyl-3,14β-dihydroxy-4, 5α- epoxymorphinan: Potential alcohol-cessation agents
Ghirmai, Senait,Azar, Marc R.,Polgar, Wilma E.,Berzetei-Gurske, Ilona,Cashman, John R.
, p. 1913 - 1924 (2008/12/21)
Substituted aryl and aliphatic amide analogues of 6-naltrexamine were synthesized and used to characterize the binding to and functional activity of human μ-, δ-, and κ-opioid receptors. Competition binding assays showed 11-25 and 27-31 bound to the μ (K
