101664-59-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3,4-dimethoxypyridine hydrochloride is used as a synthetic intermediate for the preparation of various pharmaceutical compounds. Its unique structure allows for further chemical modifications, making it a valuable building block in the development of new drugs.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-chloro-3,4-dimethoxypyridine hydrochloride serves as a key intermediate in the production of 3,4-dimethoxypyridine. This is achieved through a catalytic process involving nickel(II) chloride hexahydrate and triphenylphosphine as catalysts. The resulting 3,4-dimethoxypyridine can be further utilized in the synthesis of other complex organic molecules and compounds.

InChI:InChI=1/C7H8ClNO2/c1-10-5-3-4-9-7(8)6(5)11-2/h3-4H,1-2H3

Upstream product

• 101664-56-6 2-Chlor-3-fluor-4-nitropyridin-1-oxid 
• 109613-93-6 3,4-dimethoxypyridine 
• 101664-58-8 2-Chlor-3,4-dimethoxypyridin-1-oxid 
• 67-56-1 methanol 
• 109613-91-4 2-chloro-3-methoxy-4-nitropyridine 
• 6298-19-7 2-chloro-3-aminopyridine 
• 462-08-8 pyridin-3-ylamine 
• 85386-94-3 2-Chlor-3-fluorpyridin-1-oxid 
• 17282-04-1 2-chloro-3-fluoropyridine 

Downstream Products

• 109613-93-6 3,4-dimethoxypyridine 
• 101664-55-5 3,3',4,4'-tetramethoxy-2,2'-bipyridine 
• 72016-31-0 orelline 
• 37338-80-0 3,3',4,4'-tetrahydroxy-2,2'-bipyridine-1,1'-dioxide 
• 1204295-69-1 2-chloropyridine-3,4-diol 

Relevant academic research and scientific papers

First synthesis of 4-chloro-2,2-difluoro[1,3]dioxole[4,5-c]pyridine

The 2,2-difluorobenzodioxole moiety has been introduced in medicinal chemistry research as a potential metabolically more stable derivative of the benzodioxole fragment. Herein we present, to the best of our knowledge, the first synthesis of 4-chloro-2,2-

FUNGAL CELL WALL SYNTHESIS GENE

A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed.Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.

Syntheses of Hydroxylated Bipyridines, I. - Orellanine, the Poison of a Toadstool

Two syntheses of orellanine, -3,3',4,4'-tetrol-1,1'-dioxide (5b), are developed which comprise 10 or 11 steps, respectively.The chemical reactions of 5b with diazomethane and on UV irradiation are described.

SYNTHESIS OF ORELLANINE, THE LETHAL POISON OF A TOADSTOOL

A ten step synthesis of the structure of orellanine, 3,3',4,4'- hydroxy-2,2'-bipyridyl-bis-N-oxide (1a), is described which proves the identity of the natural product.